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Article
Open AccessNeuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington’s Disease
Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and inflammation, including microglia activation. Immunomodulatory and anti-protein aggregation properties of t...
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Article
Open AccessErratum: Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis
Scientific Reports 6: Article number: 20926; published online: 18 February 2016; updated: 13 April 2016 The original version of this Article contained an error in the title of the paper, where “Persistent acti...
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Article
Open AccessPersistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis
Cognitive impairment is common in multiple sclerosis (MS). Unfortunately, the synaptic and molecular mechanisms underlying MS-associated cognitive dysfunction are largely unknown. We explored the presence and ...
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Article
Open AccessRhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion
Mechanisms of gender-specific synaptic plasticity in the striatum, a brain region that controls motor, cognitive and psychiatric functions, remain unclear. Here we report that Rhes, a GTPase enriched in medium sp...
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Article
TrkB/BDNF-Dependent Striatal Plasticity and Behavior in a Genetic Model of Epilepsy: Modulation by Valproic Acid
In mice lacking the central domain of the presynaptic scaffold Bassoon the occurrence of repeated cortical seizures induces cell-type-specific plasticity changes resulting in a general enhancement of the feedf...
