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Article
Open AccessEpithelium-derived exosomes promote silica nanoparticles-induced pulmonary fibroblast activation and collagen deposition via modulating fibrotic signaling pathways and their epigenetic regulations
In the context of increasing exposure to silica nanoparticles (SiNPs) and ensuing respiratory health risks, emerging evidence has suggested that SiNPs can cause a series of pathological lung injuries, includin...
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Article
Open AccessRAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair
RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglu...
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Article
Open AccessAgomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to variou...
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Article
Open AccessFerroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling
Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that i...
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Article
Open AccessER Ca2+ overload activates the IRE1α signaling and promotes cell survival
Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn ac...
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Article
Liquid chromatography with tandem mass spectrometric method for determination of 425 drugs and poisons in dried blood spots and application to forensic cases
An analytical method using liquid chromatography with tandem mass spectrometry (LC–MS/MS) was established and validated for screening 425 drugs and poisons in dried blood spots (DBSs).
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Article
Open AccessWater channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a...
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Article
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries
Ferroptosis, a newly discovered form of regulated cell death dependent on iron and reactive oxygen species, is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes and the ac...
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Article
Open AccessSmall molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-...
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Article
The Negative Differential Resistance Behaviors of Zigzag GeSe Nanoribbons with Unilateral Edge Passivation via Hydrogen, Fluorine and Chlorine
Quasi-two-dimensional GeSe nanoribbons have immense potential application in nanoelectronics and photoelectronics because of their high environmental stability, earth abundance, and remarkable anisotropic phys...
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Article
Zigzag direction nanoarchitectonics of monolayer GeSe for SO2 gas sensors with high sensitivity and selectivity: a first-principles study
To meet the demands for effective detection of noxious sulfur dioxide (SO2) gas molecule, the adsorption structures and anisotropic adsorption properties of GeSe monolayer explored for non-magnetic H2, CO, CO2, N...
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Article
CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq
Single-cell RNA sequencing (scRNA-seq) is one of the most efficient technologies for human tumor research. However, data analysis is still faced with technical challenges, especially the difficulty in efficien...
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Article
Open AccessCa2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling
Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca2+) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with hu...
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Article
Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway
Soluble receptor for advanced glycation end-product (sRAGE) was reported to protect myocardial ischemia/reperfusion (I/R) injuries via directly interacting with cardiomyocytes besides competing with RAGE for A...
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Article
Soluble RAGE attenuates myocardial I/R injuries via FoxO3–Bnip3 pathway
Soluble receptor for advanced glycation end-products (sRAGE) was reported to inhibit cardiac apoptosis through the mitochondrial pathway during myocardial ischemia/reperfusion (I/R) injury. Meanwhile, the proa...
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Article
Evaluation of Tunnel Face Stability Subjected to Seismic Load Based on the Non-associated Flow Rule
Reasonable determination of the stability of the tunnel face under complex conditions is necessary for safe construction. This paper focuses on the seismic stability of the tunnel face in cohesion-frictional s...
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Article
Open AccessGanglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect that largely remains an unresolved clinical issue, leading to long-term morbidity. This meta-analysis aimed to evaluate the effi...
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Reference Work Entry In depth
DNA Damage Theory
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Article
Open AccessAquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting β-catenin degradation to enhance TopoIIα activity
Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce breast cancer mortality by 20–30%. Fu...
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Article
Open AccessAmorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage
The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confir...
