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Article
Open AccessThe VACStent trial: combined treatment of esophageal leaks by covered stent and endoscopic vacuum therapy
Endoscopic treatment of esophageal leaks, mostly by covered stents or endoscopic vacuum therapy (EVT), has largely improved the clinical outcome in the last decade. However, both techniques suffer from signifi...
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Article
Treatment of Early and Delayed Esophageal Perforation
Esophageal perforations are life threatening emergencies associated with high morbidity and mortality. We report on 22 consecutive patients (age 20–86; 13 female and 9 male) with an oesophageal perforation tre...
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Article
Splenic Artery Switch for Revascularization of the Liver: A Salvage Procedure for Inflammatory Arterial Hemorrhage
Hemorrhage caused by inflammatory vessel erosion represents a life-threatening complication after upper abdominal surgery such as pancreatic head resection. The gold standard therapeutic choice is an endovascu...
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Chapter and Conference Paper
Präkonditionierung der Rattenleber mit Hemoglobin- Glutamer 200 (OXYGLOBIN®) reduziert den Konservierungs/Reperfusionsschaden durch Hämoxegenase-1 Induktion
Introduction: Up-regulation of heme oxygenase (HO)-1 has been extensively described to decrease ischemia/reperfusion (I/R) injury in the liver. Most agents which have been used for liver ...
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Chapter and Conference Paper
Hepatocyte Growth Factor (HGF)-Konzentrationen im Patientenserum sind nach partieller Hepatektomie mit dem Ausmaß an Parenchymverlust und mit postoperativ peripher mobilisierten CD34+ und CD133+ Stammzellen positiv korreliert
In this study we investigated paracrine factors like HGF, insulin like growth factor 1 (IGF-1) stroma derived factor 1 (SDF-1) and stem cell factor (SCF) for correlation with peripheral progenitor mobilisation...
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Article
Radiotherapie von Weichteilsarkomen
Die Therapie der Weichteilsarkome hat sich von der alleinigen chirurgischen Tumorresektion zur multimodalen interdisziplinären Therapie gewandelt. Gründe hierfür sind neue Erkenntnisse in der Tumorbiologie, de...
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Article
Standard-radical vs. function-preserving surgery of benign nodular goiter—a sonographic and biochemical 10-year follow-up study
The necessary extent of thyroid resection in benign nodular goiter is under debate. The aim of our study was to compare the long-term outcome of different thyroid resection modes with special interest in the i...
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Chapter and Conference Paper
Molecular characterization of disseminated tumor cells from colorectal cancer: nuclear beta-catenin defines subpopulation with higher chromosomal instability (CIN)
The Wnt-pathway, with nuclear beta-catenin as a main effector protein, can induce Epithelial-Mesenchymal Transition (EMT) and indirectly chromosomal instability (CIN). Here, we investigated for disseminated tu...
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Chapter and Conference Paper
Neoexpression of EpCAM in Esophageal Squamous Cell Carcinoma — Prognostic Marker and Potential Therapeutic Target
EpCAM represents a relevant therapeutic target in antibody-based tumor therapy. In our study, we investigated the potential of EpCAM as a therapeutic molecular target in the treatment of esophageal squamous ce...
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Chapter and Conference Paper
Molecular analysis of early disseminated cells from esophageal cancer patients: EpCAM, a potential target for adjuvant therapy, is rarely expressed on cytokeratin-positive disseminated tumor cells
Early disseminated tumor cells (DTC) are potential precursor cells of later metastases and therefore the ultimate target for adjuvant therapies. To assess if EpCAM is a useful target for elimination of DTC in ...
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Chapter and Conference Paper
Partial Hepatectomy is paralleled by peripheral, resection-volume depending mobilisation of CD133+ stem cells
In this study we investigated peripheral progenitor mobilisation in the early course of hepatic resection using FACS-analyses in 30 patients. CT-scan volumetry pre-operatively and 24h following resection was u...
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Chapter and Conference Paper
Prognostic significance of EpCAM positive tumour cells in perirectal lymph nodes from patients with rectal carcinoma UICC stage I
Background: The evidence of lymph node metastasis is decisive for the prognosis of patients with rectal carcinoma. The aim of this study is to evaluate the prevalence and the clinical importance ...
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Chapter and Conference Paper
Down-regulation of EpCAM correlates with an unfavorable Prognosis in the Metaplasia-Carcinoma-Sequence of Barrett’s Carcinoma
EpCAM represents a promising therapeutic target in antibody-based tumor therapy. In our study, we assessed the potential of EpCAM as a therapeutic molecular target in the treatment of esophageal adenocarcinoma...
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Article
Acne inversa mit Armplexusbeteiligung
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Chapter and Conference Paper
Inzidenz und prognostische Bedeutung von okkult frühdisseminierten Tumorzellen in Lymphknoten bei Patienten mit resektablem Pankreaskarzinom
Occurrence of tumor relapse is frequent in patients with pancreatic cancer despite the absence of residual tumor detectable at primary surgery [1-4]. Therefore it has to be assumed that current tumor staging p...
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Chapter and Conference Paper
Pankreas-erhaltende Duodenektomie als chirurgische Therapieoption
Die Pankreas-erhaltende-Duodenektomie (PSD) ist eine organ-erhaltende chirurgi¬sche Therapieoption für Patienten mit Erkrankungen des Duodenums. Die Operation ist durch die besondere anatomische Nähe zwischen ...
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Chapter and Conference Paper
Rekonstruktion von großen Thoraxwanddefekten als palliatives Therapiekonzept beim exulzeriertem fortgeschrittenen Mamma-Karzinomen
Die Rekonstruktion komplexer Defekte der Thoraxwand nach ausgedehnten Resektionen bei Patientinnen mit fortgeschrittenen Mammakarzinomen stellt eine chirurgische Herausforderung dar. Patienten und Methodik: 6 Pat...
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Chapter and Conference Paper
T-banding — eine neue Technik zur Flußreduktion von seit-zu-end AV-Dialysefisteln mit zu hohem Shuntvolumen
Eine Überfunktion im Gegensatz zur nicht ausreichenden Funktion ist eine seltene Komplikation in der Dialysefistelchirurgie. Sie kann sich klinisch als steal-Phänomen mit Minderperfusion der abhängigen Extremi...
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Chapter and Conference Paper
Heterotopes Pankreas — Klinik, Lokalisation und Pathologie in elf Fällen
Heterotopes Pankreasgewebe ist eine seltene Ursache für gastrointestinale Beschwerden. Üblicherweise verursacht es keine Beschwerden, kann aber bei Größenwachstum oder im Falle chronisch entzündlicher Veränder...
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Article
Strictureplasty for large bowel stenosis in Crohn's disease: quality of life after surgical therapy
The aim of surgical therapy in Crohn's disease is to improve quality of life. Surgery does not provide cure with radical resection of inflamed bowel. Therefore strictureplasty has become a useful bowel-preserv...
