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Article
Open AccessMulticentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicen...
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Chapter
Pharmacologie et pharmacothérapie
Pharm.: Pharmacocinétique et pharmacodynamie.Termes fondamentaux et variables intervenant dans l’application, la distribution, le métabolisme et l’élimination des médicaments cytostatiques.
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Article
Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment: a single-center retrospective study
Since few studies focus on prognostic factors in unselected elderly acute myeloid leukemia (AML) patients, a retrospective analysis of 138 consecutive patients aged >55 years (median age: 67, range: 56–89) wit...
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Chapter and Conference Paper
Single-Center Retrospective Analysis of Prognosis of 138 Patients Older than 55 Years with Acute Myeloid Leukemia
Background. A retrospective analysis was performed on 138 consecutive patients aged >55 years (median age 67, range 56–89) with AML diagnosed at a single center over an 8-year period (1/1991 to 1...
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Article
Open AccessDuration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF
Cyclophosphamide, methotrexate and fluorouracil adjuvant combination chemotherapy for breast cancer is currently used for the duration of six monthly courses. We performed a joint analysis of two studies on th...
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Article
Open AccessModelling the effects of standard prognostic factors in node-positive breast cancer
Prognostic models that predict the clinical course of a breast cancer patient are important in oncology. We propose an approach to constructing such models based on fractional polynomials in which useful trans...
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Article
Therapy of small breast cancer - four-year results of a prospective non-randomized study
Background: In the early 1980s breast preservation was a rarely applied therapeutic modality in the primary treatment of breast cancer in the Federal Republic of Germany. Reports coming from retrospective studie...
