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Article
Open AccessAddressing COVID-19 challenges in a randomised controlled trial on exercise interventions in a high-risk population
The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. G...
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Article
Long-term follow-up of therapy-related myelodysplasia and AML patients treated with allogeneic hematopoietic cell transplantation
The outcome of patients with therapy-related myelodysplasia (t-MDS) or t-AML is very poor. The only curative treatment option implements allogeneic hematopoietic cell transplantation (aHCT); however, long-term...
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Article
Distribution of internal carotid artery plaque locations among patients with central retinal artery occlusion in the Eagle study population
Arterial emboli in the internal carotid artery (ICA) mainly cause cerebral ischemia; only 10 % of emboli reach the retinal arteries. Computational blood flow studies suggest that plaques situated in the ICA si...
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Article
Reduced-intensity conditioning with fludarabine and thiotepa for second allogeneic transplantation of relapsed patients with AML
A second allograft was offered to 58 relapsed AML patients after conditioning with fludarabine 90–150 mg/m2 and thiotepa 15 mg/kg, in most cases with active disease. Median age was 53 years (range 23–69), median ...
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Article
Open AccessMulticentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicen...
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Article
Open AccessSafety and tolerability of virucidal hand rubs: a randomized, double-blind, cross-over trial
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Chapter
Pharmacologie et pharmacothérapie
Pharm.: Pharmacocinétique et pharmacodynamie.Termes fondamentaux et variables intervenant dans l’application, la distribution, le métabolisme et l’élimination des médicaments cytostatiques.
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Article
Vergleich der superselektiven intraarteriellen Fibrinolyse mit konservativer Therapie
Der nichtarteriitische Zentralarterienverschluss (ZAV) ist noch immer eine Erkrankung mit schlechter Visusprognose. Als Hoffnungsträger bei der Behandlung galt die superselektive Lysetherapie, bei der ein Fibr...
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Article
Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1
The natural course of central retinal artery occlusion (CRAO) often leads to legal blindness in the affected eye. To date, none of the conservative therapies had proven effective in retrospective studies. In 1...
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Article
Die 12. Novelle des Arzneimittelgesetzes in Deutschland
Die Richtlinie 2001/20/EG des Europäischen Parlaments und des Rates vom April 2001—die so genannte Clinical Trials Directive—wurde im August 2004 in Deutschland in Form der 12. Novelle des Arzneimittelgesetzes...
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Article
Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment: a single-center retrospective study
Since few studies focus on prognostic factors in unselected elderly acute myeloid leukemia (AML) patients, a retrospective analysis of 138 consecutive patients aged >55 years (median age: 67, range: 56–89) wit...
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Chapter and Conference Paper
Single-Center Retrospective Analysis of Prognosis of 138 Patients Older than 55 Years with Acute Myeloid Leukemia
Background. A retrospective analysis was performed on 138 consecutive patients aged >55 years (median age 67, range 56–89) with AML diagnosed at a single center over an 8-year period (1/1991 to 1...
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Article
Open AccessDuration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF
Cyclophosphamide, methotrexate and fluorouracil adjuvant combination chemotherapy for breast cancer is currently used for the duration of six monthly courses. We performed a joint analysis of two studies on th...
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Article
Quantitative lymphocyte subset reconstitution after allogeneic hematopoietic transplantation from matched related donors with CD34+ selected PBPC grafts, unselected PBPC grafts or BM grafts
CD34+ cell selection of PBPC after harvest from G-CSF-treated allogeneic donors results in a more than 200-fold depletion of T lymphocytes in the graft and has been used to reduce the incidence of acute GVHD post...
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Article
Influence of recombinant human granulocyte colony-stimulating factor (filgrastim) on hematopoietic recovery and outcome following allogeneic bone marrow transplantation (BMT) from volunteer unrelated donors
Effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF, filgrastim) on hematopoietic recovery and clinical outcome in patients undergoing allogeneic bone marrow transplantation (BMT) from ...
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Article
Open AccessModelling the effects of standard prognostic factors in node-positive breast cancer
Prognostic models that predict the clinical course of a breast cancer patient are important in oncology. We propose an approach to constructing such models based on fractional polynomials in which useful trans...
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Article
NTS influence on transgene expression from mono- and bicistronic plasmid vectors after lipofection in a human fibroblast cell line
We evaluated the survival, transgene production, and copy numbers of integrated plasmid units per host genome after lipofection with mono- and bicistronic plasmid vectors in different cell lines and under var...
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Article
Therapy of small breast cancer - four-year results of a prospective non-randomized study
Background: In the early 1980s breast preservation was a rarely applied therapeutic modality in the primary treatment of breast cancer in the Federal Republic of Germany. Reports coming from retrospective studie...
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Chapter and Conference Paper
Auswirkungen von Heterogeniät auf den Vergleich von Überlebenszeiten
Dem Vergleich zweier Behandlungen im Rahmen einer klinischen Studie liegt die implizite Annahme zugrunde, daß die Zusammensetzung der Patienten innerhalb der beiden Behandlungsgruppen relativ homogen ist, bzw....
