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Article
Informing MS patients on treatment options: a consensus on the process of consent taking
In the last years, change in multiple sclerosis (MS) therapeutic scenario has highlighted the need for an improved doctor-patient communication in advance of treatment initiation in order to allow patient’s em...
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Article
Erratum: FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients
Correction to: Cell Death and Disease (2015) 6, e1741; doi:10.1038/cddis.2015.100; published online 7 May 2015 Since the publication of this paper the authors have noted that the affiliation addresses were inc...
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Article
Open AccessFAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients
Functionally distinct T-helper (Th) subsets orchestrate immune responses. Maintenance of homeostasis through the tight control of inflammatory Th cells is crucial to avoid autoimmune inflammation. Activation-I...
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Chapter
Evoluzione della malattia
La sclerosi multipla (SM) presenta manifestazioni cliniche estremamente variabili sia nelle caratteristiche di esordio sia nell’evoluzione della malattia (decorso, frequenza di ricadute, velocità di progressio...
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Article
Differential diagnosis in multiple sclerosis
Multiple sclerosis can usually be diagnosed from a patient's history, clinical examination, cerebrospinal fluid (CSF) analysis, and observations from magnetic resonance imaging (MRI). However, sometimes, the ...
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Article
The use of magnetic resonance imaging in multiple sclerosis treatment trials: power calculations for annual lesion load measurement
Phase III definitive treatment trials of new multiple sclerosis (MS) therapies now routinely incorporate an annual magnetic resonance imaging protocol, with change in T2-weighted brain lesion load providing a...
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Article
Multiple sclerosis: interobserver agreement in reporting active lesions on serial brain MRI using conventional spin echo, fast spin echo, fast fluid-attenuated inversion recovery and post-contrast T1-weighted images
Previous studies have addressed the question of the precision in assessing multiple sclerosis (MS) activity by counting enhancing lesions on gadolinium enhanced brain magnetic resonance imaging (MRI). However...
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Article
Disease activity in multiple sclerosis studied by weekly triple-dose magnetic resonance imaging
This study assessed whether dysfunction of the blood-brain barrier is an obligatory early event in lesion formation in multiple sclerosis. Dual-echo and T1-weighted magnetic resonance imaging after the inject...
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Article
Fatigue and magnetic resonance imaging activity in multiple sclerosis
Fatigue is a frequent and often severe symptom in multiple sclerosis. Pathogenic mechanisms proposed for fatigue include the release of proinflammatory cytokines, which is thought to have an important effect ...
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Article
Four-year follow-up of a case of acute multiple sclerosis of the Marburg type
We describe the clinical course, treatment and magnetic resonance findings during a four-year follow-up of a patient with acute multiple sclerosis of the Marburg type, treated with steroid and mannitol therapy...
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Article
Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome
We designed a randomized, placebo-controlled, multicentre trial involving 51 relapsing-remitting multiple sclerosis patients to determine the clinical efficacy of mitoxantrone treatment over 2 years. Patients...
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Article
High-dose contrast-enhanced MRI in multiple sclerosis
Contrast-enhanced MRI is effective for assessing disease activity in multiple sclerosis (MS) and may provide an outcome measure for testing the efficacy of treatment in clinical trials. To compare the sensitiv...
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Chapter and Conference Paper
MRI and neuropsychological correlates in presumed vascular dementia
We studied 34 patients with presumed vascular dementia (20 men and 14 women, average: 69.86) on a 0.2T MR system. T2-weighted on axial images and T1-weighted midsaggital images were obtained. The volumes of th...
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Chapter and Conference Paper
Early Treatment of Stroke in Man
According to data from the Rochester study, both stroke incidence and mortality had declined more than 50%, and long-term survival had improved over 70% from 1945–1949 to 1970–1974 (Whisnant 1983). However, no...
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Article
Irreversible total blindness in multiple sclerosis
