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  1. Article

    Marking 2-Years of New Thinking in Clinical Trials: The Estimand Journey

    The ICH E9(R1) addendum on Estimands and Sensitivity Analyses in Clinical Trials has introduced a new estimand framework for the design, conduct, analysis, and interpretation of clinical trials. We share Pharmace...

    C. Fletcher, N. Hefting, M. Wright, J. Bell… in Therapeutic Innovation & Regulatory Science (2022)

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  2. Article

    Open Access

    Connecting the dots between breast cancer, obesity and alcohol consumption in middle-aged women: ecological and case control studies

    Breast cancer (BC) incidence in Australian women aged 45 to 64 years (‘middle-aged’) has tripled in the past 50 years, along with increasing alcohol consumption and obesity in middle-age women. Alcohol and obe...

    E. R. Miller, C. Wilson, J. Chapman, I. Flight, A.-M. Nguyen… in BMC Public Health (2018)

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    Article

    Multi-spectral map** of reef bathymetry and coral cover; Kailua Bay, Hawaii

    We used high-resolution, airborne, digital, multi-spectral imagery to map bathymetry and the percent of living coral in the nearshore marine environment of Kailua Bay, Oahu, Hawai'i. Three spectral bands, with...

    E. Isoun, C. Fletcher, N. Frazer, J. Gradie in Coral Reefs (2003)

  4. No Access

    Article

    Malignant mesenchymomas of soft tissue associated with numerous osteoclast-like giant cells mimicking the so-called giant cell variant of “malignant fibrous histiocytoma”

    Three cases of malignant mesenchymoma with numerous osteoclast-like giant cells, arising in deep soft tissue, and which mimicked the so-called giant cell variant of “malignant fibrous histiocytoma” have been s...

    T. Mentzel, C. Fletcher in Virchows Archiv (1994)

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    Article

    'Macrophages' and their putative significance in human breast cancer

    JP van Netten, BJ Ashmed, D Cavers, C Fletcher, IG Thornton… in British Journal of Cancer (1992)

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    Article

    Expression of members of the myf gene family in human rhabdomyosarcomas

    Northern analysis of tumour RNA has been used to examine the expression of members of the myf family of muscle determining genes (myf3, myf4, myf5 and myf6) in a series of 20 rhabdomyosarcomas. A 2.0 kb myf3 t...

    J Clark, PJ Rocques, T Braun, E Bober, HH Arnold, C Fisher… in British Journal of Cancer (1991)

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    Chapter

    Mechanism of the Cytotoxic Interaction between ET-18-OMe and Heat

    Ether lipid analogues of platelet-activating factor have been shown to kill cancer cells either alone or in combination with other cancer chemotherapeutic agents (1–3). Recently, we have shown that one of the ...

    K. Fujiwara, C. Fletcher, E. J. Modest… in Eicosanoids and Other Bioactive Lipids in … (1991)

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    Article

    Concerted contractions of tumour fragments derived from a pure mucoid carcinoma of the breast in vitro

    Organized tissue fragments obtained by dissociation of a pure mucoid carcinoma of the breast were cultured in vitro. The cellular organization of the fragments appcars similar to that observed in vivo, and con...

    J. P. van Netten, R. L. Racca… in Journal of Cancer Research and Clinical On… (1988)