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Mechanism of the Cytotoxic Interaction between ET-18-OMe and Heat

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Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 67))

Abstract

Ether lipid analogues of platelet-activating factor have been shown to kill cancer cells either alone or in combination with other cancer chemotherapeutic agents (1–3). Recently, we have shown that one of the ether lipid analogues, ET-18-OMe1, and 44°C hyperthermia interact supra-additively to kill BG-1 human ovarian carcinoma cells at concentration ≤0.5 μM of ET-18-OMe and additively at higher concentrations (0.5 to 2.0 μM) of ET-18-OMe (4). The mechanism of this cytotoxic interaction of ET-18-OMe and heat is presently unknown. In this study, we examine flow cytometrically two parameters, cell cycle distribution and nuclear protein content, that are altered after heat treatment to determine if they are involved in the mechanism governing the interaction of heat and ET-18-OMe.

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References

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Authors and Affiliations

  1. Departments of Radiology and Biochemistry, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC, 27103, USA

    K. Fujiwara, C. Fletcher, E. J. Modest & C. A. Wallen

Authors
  1. K. Fujiwara
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  2. C. Fletcher
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  3. E. J. Modest
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  4. C. A. Wallen
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  2. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  3. Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

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© 1991 Springer Science+Business Media New York

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Fujiwara, K., Fletcher, C., Modest, E.J., Wallen, C.A. (1991). Mechanism of the Cytotoxic Interaction between ET-18-OMe and Heat. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_69

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  • DOI: https://doi.org/10.1007/978-1-4615-3874-5_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6727-7

  • Online ISBN: 978-1-4615-3874-5

  • eBook Packages: Springer Book Archive

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