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Chapter
Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes
Heme mediated oxidative toxicity has been linked to adverse side effects in Hemoglobin Based Oxygen Carriers (HBOC), initiated by reactive ferryl (FeIV) iron and globin based free radical species. We recently sho...
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Chapter
Near Infrared Spectroscopy (NIRS) Observation of Vastus Lateralis (Muscle) and Prefrontal Cortex (Brain) Tissue Oxygenation During Synchronised Swimming Routines in Elite Athletes
The development of underwater Near-Infrared Spectroscopy (uNIRS) has enabled the measurement of tissue oxygenation within the swim environment. Unique physiological responses, such as the diving reflex, have b...
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Chapter and Conference Paper
Underwater Near-Infrared Spectroscopy: Muscle Oxygen Changes in the Upper and Lower Extremities in Club Level Swimmers and Triathletes
To date, measurements of oxygen status during swim exercise have focused upon systemic aerobic capacity. The development of a portable, waterproof NIRS device makes possible a local measurement of muscle hemod...
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Chapter and Conference Paper
The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute
It has been proposed that introducing tyrosine residues into human hemoglobin (e.g. βPhe41Tyr) may be able to reduce the toxicity of the ferryl heme species in extracellular hemoglobin-based oxygen carriers (H...
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Chapter and Conference Paper
Use of NIRS to Assess Effect of Training on Peripheral Muscle Oxygenation Changes in Elite Rugby Players Performing Repeated Supramaximal Cycling Tests
In most team sports, intermittent high intensity sprint efforts combined with short recovery periods have been identified as a key factor of physical performance; the ability to repeat these efforts at a susta...