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HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD)
Huntington disease (HD) is a chronic, debilitating genetic disease that affects physical, emotional, cognitive, and social health. Existing patient-reported outcomes (PROs) of health-related quality of life (H...
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Article
Functional nanostructured materials based on self-assembly of block copolymers
Block copolymers (BCPs) microphase-separate to form periodic patterns with periods of a few nanometers and above without the need for lithographic guidance. These self-assembled nanostructures have a variety o...
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Article
Open AccessLogic circuit prototypes for three-terminal magnetic tunnel junctions with mobile domain walls
Spintronic computing promises superior energy efficiency and nonvolatility compared to conventional field-effect transistor logic. But, it has proven difficult to realize spintronic circuits with a versatile, ...
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A mutation in NPAS3 segregates with mental illness in a small family
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A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice
The pathogenesis of obesity remains incompletely understood and the exploration of the role of novel proteins in obesity may provide important insights into its causes and treatments. Here, we report a previou...
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Article
On-chip optical isolation in monolithically integrated non-reciprocal optical resonators
Non-reciprocal photonic devices, including optical isolators and circulators, are indispensible components in optical communication systems. However, the integration of such devices on semiconductor platforms ...
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Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation
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Open AccessDifferential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders. Recent studies have shown that DISC1 has ...
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Article
Complex self-assembled patterns using sparse commensurate templates with locally varying motifs
Templated self-assembly of block copolymer thin films can generate periodic arrays of microdomains within a sparse template, or complex patterns using 1:1 templates1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16. However,...
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Article
Thermal Annealing Influence on Magnetic and Structural Properties of Cu56Ga28Mn16 Microwires
We report on the crystalline structure, morphology and thermomagnetic properties of glass-coated magnetic microwires with Cu56Ga28Mn16 composition, as well as the thermal annealing influence on its magneto-struct...
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Article
Magnetocaloric properties of rapidly solidified Ni51.1Mn31.2In17.7 Heusler alloy ribbons
Magnetic entropy change and refrigerant capacity have been determined for a field change of 20 kOe around the second-order magnetic transition of austenite in as-quenched Ni{in51.1}Mn{in31.2}In{in17.7} alloy r...
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Article
Patterned Magnetic Media Made by Self-Assembled Block-Copolymer Lithography
Patterned magnetic recording media, in which data bits are stored in discrete single-domain magnetic particles, have been proposed for the next generation of recording media. To achieve high densities, feature...
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Article
Inaugural Huntington Disease Clinical Research Symposium Organized by the Huntington Study Group
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Article
Large Magnetoresistance Variation of Pseudo Spin Valves with Different Nano Oxide Layer Position
We have investigated the influence of the nano-oxide layer positions on giant magnetoresistance(GMR) of the NiFe(9nm)/Cu(4nm)/Co(5nm) pseudo spin valves. Nano-oxide layer positions had a several effects on the...
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Enlargement of the lateral ventricles in mutant DISC1 transgenic mice
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Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia
A strong candidate gene for schizophrenia and major mental disorders, disrupted-in-schizophrenia 1 (DISC1) was first described in a large Scottish family in which a balanced chromosomal translocation segregate...
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Article
A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array
CAG/CTG repeat expansions cause at least 12 different neurological disorders, and additional disorders of this type probably exist. Using the repeat expansion detection (RED) assay, we identified an expanded C...
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A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder
In a large Scottish pedigree, a balanced translocation t(1;11)(q42.1;q14.3) segregates with major mental illness, including schizophrenia, bipolar disorder, and recurrent major depression. The translocation is...
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A method for making substrate-independent hardness measurements of soft metallic films on hard substrates by nanoindentation
A new method for making substrate-independent hardness measurements by nanoindentation techniques that applies to soft metallic films on very hard substrates is presented. The primary issue to be addressed is ...
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Article
Trap** and sequence analysis of 1138 putative exons from human chromosome 18
In a search for novel genes on chromosome 18 (HC18), on which several regions have been linked to bipolar disorder, we applied exon trap** to HC18-specific cosmids. Among the 1138 exons trapped, 1052 of them ha...