24 Result(s)

Article

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals’ brai...

P-M Martin, R E Stanley, A P Ross, A E Freitas, C E Moyer… in Molecular Psychiatry (2018)

Article

High-throughput sequencing of the synaptome in major depressive disorder

Major depressive disorder (MDD) is among the leading causes of worldwide disability. Despite its significant heritability, large-scale genome-wide association studies (GWASs) of MDD have yet to identify robust...

M Pirooznia, T Wang, D Avramopoulos, J B Potash, P P Zandi… in Molecular Psychiatry (2016)

Article

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute...

W J Peyrot, S H Lee, Y Milaneschi, A Abdellaoui, E M Byrne, T Esko… in Molecular Psychiatry (2015)

Article

Metamoodics: meta-analysis and bioinformatics resource for mood disorders

M Pirooznia, F Seifuddin, J Judy, F S Goes, J B Potash, P P Zandi in Molecular Psychiatry (2014)

Article

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants

We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing d...

E R Gamazon, J A Badner, L Cheng, C Zhang, D Zhang, N J Cox… in Molecular Psychiatry (2013)

Article

Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms

Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in m...

J A Badner, D Koller, T Foroud, H Edenberg, J I Nurnberger Jr… in Molecular Psychiatry (2012)

Article

A genome-wide association study of attempted suicide

The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. Although attempted suicide linkage regions have been identified on 2p1...

V L Willour, F Seifuddin, P B Mahon, D Jancic, M Pirooznia… in Molecular Psychiatry (2012)

Article

Genome-wide association study of recurrent early-onset major depressive disorder

A genome-wide association study was carried out in 1020 case subjects with recurrent early-onset major depressive disorder (MDD) (onset before age 31) and 1636 control subjects screened to exclude lifetime MDD...

J Shi, J B Potash, J A Knowles, M M Weissman, W Coryell… in Molecular Psychiatry (2011)

Article

Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies

We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR^*D) study and 1636 screened controls. No geno...

S I Shyn, J Shi, J B Kraft, J B Potash, J A Knowles, M M Weissman… in Molecular Psychiatry (2011)

Article

Genome-wide association study of bipolar disorder in European American and African American individuals

To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 contr...

E N Smith, C S Bloss, J A Badner, T Barrett, P L Belmonte… in Molecular Psychiatry (2009)

Article

Singleton deletions throughout the genome increase risk of bipolar disorder

An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genom...

D Zhang, L Cheng, Y Qian, N Alliey-Rodriguez, J R Kelsoe… in Molecular Psychiatry (2009)

Article

Family-based association of FKBP5 in bipolar disorder

The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and ...

V L Willour, H Chen, J Toolan, P Belmonte, D J Cutler, F S Goes… in Molecular Psychiatry (2009)

Article

Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates

Despite compelling evidence that genetic factors contribute to bipolar disorder (BP), attempts to identify susceptibility genes have met with limited success. This may be due to the genetic heterogeneity of th...

P P Zandi, J A Badner, J Steele, V L Willour, K Miao, D F MacKinnon… in Molecular Psychiatry (2007)

Article

Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis

Our group first reported a linkage finding for bipolar (BP) disorder on chromosome 8q24 in a study of 50 multiplex pedigrees, with an HLOD score reaching 2.39. Recently, Cichon et al reported an LOD score of 3.62...

D Avramopoulos, V L Willour, P P Zandi, Y Huo, D F MacKinnon… in Molecular Psychiatry (2004)