7 Result(s)

Article

Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell… in Nature Communications (2024)

Article

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune s...

Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell… in Nature Communications (2023)

Article

γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in...

Juan F. Quintana, Matthew C. Sinton, Praveena Chandrasegaran… in Nature Communications (2023)

Article

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

Human African trypanosomiasis, or slee** sickness, is caused by the protozoan parasite Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation when the parasites colonise the cen...

Juan F. Quintana, Praveena Chandrasegaran, Matthew C. Sinton… in Nature Communications (2022)

Article

Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress

Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood. In prete...

Eamon Fitzgerald, Matthew C. Sinton, Sara Wernig-Zorc… in Epigenetics & Chromatin (2021)

Article

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein, we address this critical gap in kn...

Karla J. Suchacki, Adriana A. S. Tavares, Domenico Mattiucci… in Nature Communications (2020)

Article

Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome

Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 24% of the global adult population. NAFLD is a major risk factor for the development of cirrhosis and hepatocellular carcinoma, as well as being...

Matthew C. Sinton, David C. Hay, Amanda J. Drake in Clinical Epigenetics (2019)