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Open AccessGenetic variation regulates opioid-induced respiratory depression in mice
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse of prescription opioids along with increased use of drugs like heroin and fentanyl, has led ...
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Article
Open AccessA comparative study of sleep and diurnal patterns in house mouse (Mus musculus) and Spiny mouse (Acomys cahirinus)
Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mamm...
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Open AccessNovel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury
Traumatic brain injury (TBI) begins with the application of mechanical force to the head or brain, which initiates systemic and cellular processes that are hallmarks of the disease. The pathological cascade of...
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Open AccessAnalysis of sleep traits in knockout mice from the large-scale KOMP2 population using a non-invasive, high-throughput piezoelectric system
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Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse
Following mild traumatic brain injury (TBI), patients may self-treat symptoms of concussion, including post-traumatic headache, taking over-the-counter (OTC) analgesics. Administering one dose of OTC analgesic...
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Open AccessMeditation acutely improves psychomotor vigilance, and may decrease sleep need
A number of benefits from meditation have been claimed by those who practice various traditions, but few have been well tested in scientifically controlled studies. Among these claims are improved performance ...
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Open AccessAssessment of a non-invasive high-throughput classifier for behaviours associated with sleep and wake in mice
This work presents a non-invasive high-throughput system for automatically detecting characteristic behaviours in mice over extended periods of time, useful for phenoty** experiments. The system classifies t...
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Open AccessA non-circadian role for clock-genes in sleep homeostasis:a strain comparison
We have previously reported that the expression of circadian clock-genes increases in the cerebral cortex after sleep deprivation (SD) and that the sleep rebound following SD is attenuated in mice deficient fo...
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Free Communication Abstracts
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Open AccessA role for cryptochromesin sleep regulation
The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack circadian rhythms. We studied sleep in cry1,2-/- mice und...
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HSP70 expression is increased during the day in a diurnal animal, the golden-mantled ground squirrelSpermophilus lateralis
Heat shock protein 70 (HSP70) gene expression was studied in a seasonal hibernator, the diurnal ground squirrel, Spermophilus lateralis. RNA transcripts of 2.7 and 2.9 kb hybridizing to an HSP70 cDNA were expr...
