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Article
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of Alzheimer’s...
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Article
Open AccessCorpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease
Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular org...
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Article
Open AccessA comparative study of sleep and diurnal patterns in house mouse (Mus musculus) and Spiny mouse (Acomys cahirinus)
Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mamm...
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Article
Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors
As we age, we experience changes in our nighttime sleep and daytime wakefulness. Individuals afflicted with Alzheimer’s disease (AD) can develop sleep problems even before memory and other cognitive deficits a...
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Article
Open AccessLongitudinal data methods for evaluating genome-by-epigenome interactions in families
Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correl...
