-
Article
Open AccessEvaluation of different types of face masks to limit the spread of SARS-CoV-2: a modeling study
We expanded a published mathematical model of SARS-CoV-2 transmission with complex, age-structured transmission and with laboratory-derived source and wearer protection efficacy estimates for a variety of face...
-
Article
Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies
Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical industry. More than 25 mAbs and derivatives have been...
-
Chapter and Conference Paper
Controlling for Population Variances in Health and Exposure Risk Using Randomized Matrix Based Mathematical Modeling
In a previous work, we analyzed the co-occurrence of HPV types in 6 large studies with cervicovaginal samples, representing >32,000 women, to ascertain if associations exist among HPV types and to guide polici...
-
Article
Open AccessFunctional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression and Disease Association
Serotonergic neurotransmission plays a key role in the pathophysiology of neuropsychiatric illnesses. The functional significance of a promoter polymorphism, −1438G/A (rs6311), in one of the major genes of thi...
-
Article
Open AccessQuadratic variance models for adaptively preprocessing SELDI-TOF mass spectrometry data
Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) is a proteomics tool for biomarker discovery and other high throughput applications. Previous studies have identified vario...
-
Article
Open AccessInclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability
The body's primary stress management system is the hypothalamic pituitary adrenal (HPA) axis. The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's co...
