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Open AccessPredicting sites of ADAR editing in double-stranded RNA
ADAR (adenosine deaminase that acts on RNA) editing enzymes target coding and noncoding double-stranded RNA (dsRNA) and are essential for neuronal function. Early studies showed that ADARs preferentially targe...
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Article
The short answer
One way of seeing what a gene does is to block its messenger RNA and note the effects. New work should make the approach more broadly applicable.
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Erratum: RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase
Nature 380, 454-456 (1996) DETAILS for correspondence regarding this work were incomplete as published: correspondence and requests for materials should be addressed to B.L.B. (on dsRAD) or to J.L.C. (on HDV)....
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RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase
HEPATITIS delta virus (HDV) is a subviral human pathogen that requires hepatitis B virus (HBV) for packaging1,2. Concurrent infection by HBV and HDV increases the risk of severe liver disease compared to infectio...
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Splicing: the new edition
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Physarum — C the difference?
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Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA
Splicing of the ribosomal RNA precursor of Tetrahymena has previously been shown to require no protein in vitro; the cleavage–ligation activity is intrinsic to the RNA molecule. Analysis of the reaction kinetics ...