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  1. No Access

    Article

    Apoptosis in BEL-7402 cells induced by ruthenium(II) complexes through a ROS-mediated mitochondrial pathway

    Three Ru(II) polypyridyl complexes [Ru(dmb)2(HMSPIP)](ClO4)2 (1), [Ru(phen)2(HMSPIP)](ClO4)2 (2) and [Ru(dmp)2(HMSPIP)](ClO4)2 (3) were synthesized and characterized. The cytotoxicity in vitro, apoptosis, cell cy...

    Guang-Bin Jiang, Wei Li, Ji Wang, Bing-Jie Han, Gan-Jian Lin… in Transition Metal Chemistry (2014)

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    Article

    Ruthenium(II) polypyridyl complexes: synthesis, cytotoxicity in vitro, reactive oxygen species, mitochondrial membrane potential and cell cycle arrest studies

    Two Ru(II) polypyridyl complexes [Ru(dmb)2(idpq)](ClO4)2 (1) (idpq = indeno[1,2-b]dipyrido[3,2-f:2′,3′-h]-quinoxaline-6-one, dmb = 4,4′-dimethyl-2,2′-bipyridine) and [Ru(bpy)2(idpq)](ClO4)2 (2) (bpy = 2,2′-bipyr...

    Bing-Jie Han, Guang-Bin Jiang, Ji Wang, Wei Li… in Transition Metal Chemistry (2015)

  3. No Access

    Article

    Synthesis, Molecular Structure, DNA/Protein Binding, Cytotoxicity, Apoptosis, Reactive Oxygen Species, and Mitochondrial Membrane Potential of Dibenzoxanthenes Derivatives

    Two dibenzoxanthene isomers 3 and 4 were synthesized and characterized. The crystal structures of the two compounds were solved by single-crystal X-ray diffraction. Binding of two compounds with calf thymus DNA (...

    Hui-Hui Yang, Bing-Jie Han, Wei Li, Yun-Jun Liu… in The Journal of Membrane Biology (2015)

  4. No Access

    Article

    DNA-Binding, Photocleavage, and Photodynamic Anti-cancer Activities of Pyridyl Corroles

    The DNA-binding, photocleavage, and antitumor activity of three free base pyridyl corroles 1, 2, and 3 have been investigated. The binding affinity toward CT-DNA decreases with increasing number of pentafluorophe...

    Zhen-Hua Liang, Hai-Yang Liu, Rong Zhou, Zao Zhang… in The Journal of Membrane Biology (2016)

  5. No Access

    Article

    Synthesis, biological activities studies of ruthenium(II) polypyridyl complexes

    Four ruthenium(II) polypyridyl complexes were synthesized and characterized by elemental analysis, IR, ESI-MS and 1H NMR. The in vitro cytotoxicities of the complexes against BEL-7402, HeLa, A549, HepG2 and MG-63...

    Bing Tang, Bing-Jie Han, Dan Wan, Shang-Hai Lai… in Transition Metal Chemistry (2017)