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Synthesis, biological activities studies of ruthenium(II) polypyridyl complexes

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Abstract

Four ruthenium(II) polypyridyl complexes were synthesized and characterized by elemental analysis, IR, ESI-MS and 1H NMR. The in vitro cytotoxicities of the complexes against BEL-7402, HeLa, A549, HepG2 and MG-63 cancer cells were investigated by MTT methods, giving IC50 values ranging from 6.9 to 43.5 μM. The complexes show their highest inhibitory effect on MG-63 cells, but no cytotoxic activities against HeLa cells. Cellular uptake experiments indicate that the complexes can enter the cytoplasm and accumulate in the cell nuclei. The complexes can induce apoptosis in MG-63 cells, enhance the levels of reactive oxygen species, and induce a decrease in mitochondrial membrane potential. The cell cycle distribution shows that the complexes induce cell cycle arrest at S phase in MG-63 cells. Additionally, these complexes can up-regulate the levels of Bad and Bid expression and down-regulate the expression of Bcl-2 and Bcl-x.

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Acknowledgements

This work was supported by the Natural Science foundation of Guangdong Province (No. 2016A030313728), the High-Level Personnel Project of Guangdong Province in 2013 and the Joint Nature Science Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University (No. GYFYLH201315) and the Project of Innovation for Enhancing Guangdong Pharmaceutical University, Provincial Experimental Teaching Demonstration Center of Chemistry and Chemical Engineering.

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Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China

    Bing Tang, Bing-Jie Han, Dan Wan, Shang-Hai Lai, **u-Zhen Wang, Cheng Zhang, Chuan-Chuan Zeng & Yun-Jun Liu

  2. Guangdong Cosmetics Engineering and Technology Research Center, Guangzhou, 510006, People’s Republic of China

    Yun-Jun Liu

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  1. Bing Tang
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Correspondence to **u-Zhen Wang or Yun-Jun Liu.

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Tang, B., Han, BJ., Wan, D. et al. Synthesis, biological activities studies of ruthenium(II) polypyridyl complexes. Transit Met Chem 42, 373–386 (2017). https://doi.org/10.1007/s11243-016-0106-8

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  • DOI: https://doi.org/10.1007/s11243-016-0106-8

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