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    Article

    Apoptosis in BEL-7402 cells induced by ruthenium(II) complexes through a ROS-mediated mitochondrial pathway

    Three Ru(II) polypyridyl complexes [Ru(dmb)2(HMSPIP)](ClO4)2 (1), [Ru(phen)2(HMSPIP)](ClO4)2 (2) and [Ru(dmp)2(HMSPIP)](ClO4)2 (3) were synthesized and characterized. The cytotoxicity in vitro, apoptosis, cell cy...

    Guang-Bin Jiang, Wei Li, Ji Wang, Bing-Jie Han, Gan-Jian Lin… in Transition Metal Chemistry (2014)

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    Article

    Ruthenium(II) polypyridyl complexes: synthesis, cytotoxicity in vitro, reactive oxygen species, mitochondrial membrane potential and cell cycle arrest studies

    Two Ru(II) polypyridyl complexes [Ru(dmb)2(idpq)](ClO4)2 (1) (idpq = indeno[1,2-b]dipyrido[3,2-f:2′,3′-h]-quinoxaline-6-one, dmb = 4,4′-dimethyl-2,2′-bipyridine) and [Ru(bpy)2(idpq)](ClO4)2 (2) (bpy = 2,2′-bipyr...

    Bing-Jie Han, Guang-Bin Jiang, Ji Wang, Wei Li… in Transition Metal Chemistry (2015)

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    Article

    Synthesis, biological activities studies of ruthenium(II) polypyridyl complexes

    Four ruthenium(II) polypyridyl complexes were synthesized and characterized by elemental analysis, IR, ESI-MS and 1H NMR. The in vitro cytotoxicities of the complexes against BEL-7402, HeLa, A549, HepG2 and MG-63...

    Bing Tang, Bing-Jie Han, Dan Wan, Shang-Hai Lai… in Transition Metal Chemistry (2017)