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Life Sciences
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Article
Open AccessTranscriptome analysis of Gossypium hirsutum cultivar Zhongzhimian No.2 uncovers the gene regulatory networks involved in defense against Verticillium dahliae
Cotton is globally important crop. Verticillium wilt (VW), caused by Verticillium dahliae, is the most destructive disease in cotton, reducing yield and fiber quality by over 50% of cotton acreage. Breeding resis...
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IRE1α: from the function to the potential therapeutic target in atherosclerosis
Inositol requiring enzyme 1 (IRE1) is generally thought to control the most conserved pathway in the unfolded protein response (UPR). Two isoforms of IRE1, IRE1α and IRE1β, have been reported in mammals. IRE1α...
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Comparative molecular dynamics simulations provided insights into the mechanisms of cold-adaption of alginate lyases from the PL7 family
Alginate is an important polysaccharide that is abundant in the marine environments, including the Polar Regions, and bacterial alginate lyases play key roles in its degradation. Many reported alginate lyases ...
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Open AccessTektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella
Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is pr...
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Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis and aging. DNA methylation patterns are formed by precisely...
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Open AccessHelicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis
There is a link between Helicobacter pylori (HP) infection and small intestinal bacterial overgrowth (SIBO) with nonspecific digestive symptoms. Nonetheless, whether HP infection is associated with SIBO in adults...
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Study on the effect of enzymatic treatment of tobacco on HnB cigarettes and microbial succession during fermentation
Starch and cellulose are the fundamental components of tobacco, while their excessive content will affect the quality of tobacco. Enzymatic treatment with different enzymes is a promising method to modulate th...
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Open AccessA patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that functional LGI1 is secreted by excitator...
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Open AccessUpregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma
The response of advanced clear cell renal cell carcinoma (ccRCC) to immunotherapy is still not durable, suggesting that the immune landscape of ccRCC still needs to be refined, especially as some molecules tha...
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Role of Sp1 in atherosclerosis
Specificity protein (Sp) is a famous family of transcription factors including Sp1, Sp2 and Sp3. Sp1 is the first one of Sp family proteins to be characterized and cloned in mammalian. It has been proposed tha...
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Correction to: Fluorescence recovery after photobleaching: analyses of cyanobacterial phycobilisomes reveal intrinsic fluorescence recovery
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Fluorescence recovery after photobleaching: analyses of cyanobacterial phycobilisomes reveal intrinsic fluorescence recovery
Fluorescence recovery after photobleaching (FRAP) has been used to study the dynamics of the cyanobacterial photosynthesis apparatus since 1997. Fluorescence recovery of cyanobacteria during FRAP was conventio...
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Open AccessRole of GALNT4 in protecting against cardiac hypertrophy through ASK1 signaling pathway
Pathological myocardial hypertrophy is regulated by multiple pathways. However, its underlying pathogenesis has not been fully explored. The goal of this work was to elucidate the function of polypeptide N-ace...
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Open AccessAssociation between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations
CCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the ...
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Open AccessComparative genomics reveals broad genetic diversity, extensive recombination and nascent ecological adaptation in Micrococcus luteus
Micrococcus luteus is a group of actinobacteria that is widely used in biotechnology and is being thought as an emerging nosocomial pathogen. With one of the smallest genomes of free-living actinobacteria, it is ...
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Open AccessA small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
Residual disease is the major cause for colorectal cancer (CRC) relapse. Herein, we explore whether and how a natural molecule CADPE killed heterogenic populations in a panel of CRC cell lines with KRAS/BRAF m...
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Correction to: Simulated microgravity significantly altered metabolism in epidermal stem cells
The affiliation given for Yan Cui in this article is not correct. The following is the correction affiliation
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The equilibrium between sugars and ethylene is involved in shading- and drought-induced kernel abortion in maize
Shading and drought stresses during the flowering stage of maize (Zea mays L.) production cause seed losses, making them two of the major limitations to yield output. The mechanisms by which the two stresses redu...
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Rapid detection of Anguina agrostis by loop-mediated isothermal amplification
Anguina agrostis is an important grass parasitic nematode and listed as an agricultural and quarantine pest in various countries. It is difficult to identify it based simply on morphology. A loop-mediated isother...
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Open AccessSimulated microgravity significantly altered metabolism in epidermal stem cells
Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia...
