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  1. No Access

    Chapter

    PET Imaging of Purinergic Receptors

    Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processe...

    Bieneke Janssen, Danielle J. Vugts… in PET and SPECT of Neurobiological Systems (2021)

  2. Article

    Open Access

    PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139

    Non-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide valuable insights not only into pathogenesis of neuro-inflammatory and...

    Wissam Beaino, Bieneke Janssen, Esther Kooijman… in Journal of Neuroinflammation (2020)

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  3. Article

    Open Access

    Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

    Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia in vivo is highly dynamic and occurs as a continuu...

    Wissam Beaino, Bieneke Janssen, Gijs Kooij… in Journal of Neuroinflammation (2017)

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  4. No Access

    Chapter

    Imaging Histamine Receptors Using PET and SPECT

    The histaminergic system contains four subtypes of G-protein-coupled receptors: H1R, H2R, H3R and H4R. In the central nervous system, they mediate the action of histamine in pituitary hormone secretion, wakefulne...

    Uta Funke, Danielle J. Vugts, Bieneke Janssen… in PET and SPECT of Neurobiological Systems (2014)