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Article
Open AccessPolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral sclerosis (C9ALS)/frontotemporal dementia (FTD) pathology, but their physiological impact has yet to be fully determined. He...
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Article
Open AccessQuantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women
A non-invasive endometrial cancer detection tool that can accurately triage symptomatic women for definitive testing would improve patient care. Urine is an attractive biofluid for cancer detection due to its ...
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Article
Open AccessApplication of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis
Weight gain is a common consequence of treatment with antipsychotic drugs in early psychosis, leading to further morbidity and poor treatment adherence. Identifying tools that can predict weight change in earl...
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Article
Open AccessEVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal
The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To inves...
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Article
Open AccessAnalysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods
Palmitoylation is a reversible post-translational protein modification in which palmitic acid is added to cysteine residues, allowing association with different cellular membranes and subdomains. Recently, tec...
