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Article
Does levelling of T1 tilt intra-operatively affect post-operative shoulder balance in adolescent idiopathic scoliosis patients?
Previous studies have shown that T1 tilt is positively correlated with post-operative shoulder balance (SB). The aim of this study was to explore the role of intra-operative T1 tilt, among other shoulder param...
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Article
Open AccessQuantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women
A non-invasive endometrial cancer detection tool that can accurately triage symptomatic women for definitive testing would improve patient care. Urine is an attractive biofluid for cancer detection due to its ...
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Article
Open AccessHMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block
Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activit...
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Article
Open AccessChanges in the incidence of seasonal influenza in response to COVID-19 social distancing measures: an observational study based on Canada’s national influenza surveillance system
Seasonal influenza is an acute respiratory infection that presents a significant annual burden to Canadians and the Canadian healthcare system. Social distancing measures that were implemented to control the 2...
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Chapter
“Stop, Stop and Listen”: Changing the Church by Listening to Its Life
This chapter asks if the current official account of Anglican ecclesiological identity is fit for purpose, and argues that the evidence to-date points clearly to an answer in the negative. Since 1987, the clai...
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Article
Open AccessEVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal
The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To inves...
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Article
Open AccessEVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle
Aberrantly high expression of EVI1 in acute myeloid leukaemia (AML) is associated with poor prognosis. For targeted treatment of EVI1 overexpressing AML a more detailed understanding of aspects of spatiotemporal ...
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Article
Open AccessIntegrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compare...
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Article
Plasma insulin-like growth factor-1 is unrelated to female reproductive development in a wild population of Dolly Varden charr Salvelinus malma (Walbaum, 1792)
Insulin-like growth factors (IGFs) are endocrine agents that signal growth in fishes. Because of the interplay between growth and reproduction, endocrine control of the growth axis is thought to have a connect...
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Article
Open AccessAcquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenoty** of BRCA2 disruption
BRCA2 encodes a protein with a fundamental role in homologous recombination that is essential for normal development. Carrier status of mutations in BRCA2 is associated with familial breast and ovarian cancer, wh...
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Article
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has revolutionized disease management, ...
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Article
Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines
This protocol uses a highly sensitive and reproducible antibody-based capillary isoelectric focusing approach to establish protein phosphorylation status from nanogram quantities of protein cell lysate from ce...
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Article
BCR–ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor
Chronic myeloid leukaemia (CML), a hematopoietic stem cell disorder is characterized by the expression of BCR–ABL. To investigate the effects of BCR–ABL on multipotent hematopoietic cells, a temperature sensit...
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Article
Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation
Chronic myeloid leukaemia is a haemopoietic stem cell disorder, the hallmark of which is the expression of the Bcr-Abl Protein Tyrosine Kinase (PTK). We have previously reported that activation of a temperatur...
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Article
The Effect of Bcr-Abl Protein Tyrosine Kinase on Maturation and Proliferation of Primitive Haematopoietic Cells
Chronic Myeloid Leukaemia (CML) is characterised by the chromosomal translocation resulting in expression of the Bcr-Abl protein tyrosine kinase (PTK) in early stem cells and their progeny. However the precise...
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Article
Influence of chemotherapeutants and cytokines on growth and transgene expression of bone marrow cells from MT/P210bcr-ab1 transgenic mice
Objective: To investigate the influence of chemotherapeutic agents and cytokines on growth of bone marrow cells from MT/p210bcr-abl transgenic mice. Methods: The bone marrow cells of transgenic chronic myelogenou...
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Article
p210 Bcr–Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia
Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haemopoietic stem cell, the hallmark of which is the constitutively activated Bcr–Abl protein tyrosine kinase. During the initial chronic...
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Chapter
Cellular and Molecular Aspects of Myeloid Cell Proliferation and Development
Stem cells give rise to all the different types of blood cell. These pluripotent cells undergo self-renewal and differentiation to produce more developmentally restricted cells, which proliferate and develop t...
