56 Result(s)
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Bernt Guldbrandtsen
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Article
Open AccessGene Editing Cattle for Enhancing Heat Tolerance: A Welfare Review of the “PRLR-SLICK Cattle” Case
In March 2022 the US Food and Drug Administration (FDA) published a risk assessment of a recent animal gene editing proposal submitted by Acceligen™. The proposal concerned the possibility of changing the catt...
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Open AccessImpact of kinship matrices on genetic gain and inbreeding with optimum contribution selection in a genomic dairy cattle breeding program
Genomic selection has increased genetic gain in dairy cattle, but in some cases it has resulted in higher inbreeding rates. Therefore, there is need for research on efficient management of inbreeding in genomi...
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Open AccessInbreeding and pedigree analysis of the European red dairy cattle
Red dairy cattle breeds have an important role in the European dairy sector because of their functional characteristics and good health. Extensive pedigree information is available for these breeds and provide...
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Open AccessAssessing the genetic background and genomic relatedness of red cattle populations originating from Northern Europe
Local cattle breeds need special attention, as they are valuable reservoirs of genetic diversity. Appropriate breeding decisions and adequate genomic management of numerically smaller populations are required ...
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Correction to: The application of deep learning for the classification of correct and incorrect SNP genotypes from whole-genome DNA sequencing pipelines
The original version on this paper contained an error. Figure 5 was published with the same image of Fig. 4.
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Open AccessThe application of deep learning for the classification of correct and incorrect SNP genotypes from whole-genome DNA sequencing pipelines
A downside of next-generation sequencing technology is the high technical error rate. We built a tool, which uses array-based genotype information to classify next-generation sequencing–based SNPs into the cor...
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Open AccessWeighted single-step genomic best linear unbiased prediction integrating variants selected from sequencing data by association and bioinformatics analyses
Sequencing data enable the detection of causal loci or single nucleotide polymorphisms (SNPs) highly linked to causal loci to improve genomic prediction. However, until now, studies on integrating such SNPs us...
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Open AccessPatterns of DNA variation between the autosomes, the X chromosome and the Y chromosome in Bos taurus genome
The new ARS-UCD1.2 assembly of the bovine genome has considerable improvements over the previous assembly and thus more accurate identification of patterns of genetic variation can be achieved with it. We expl...
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Open AccessDistinguishing pleiotropy from linked QTL between milk production traits and mastitis resistance in Nordic Holstein cattle
Production and health traits are central in cattle breeding. Advances in next-generation sequencing technologies and genotype imputation have increased the resolution of gene map** based on genome-wide assoc...
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Open AccessGenome-wide association map** for dominance effects in female fertility using real and simulated data from Danish Holstein cattle
Exploring dominance variance and loci contributing to dominance variation is important to understand the genetic architecture behind quantitative traits. The objectives of this study were i) to estimate domina...
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Open AccessWhole genome sequence and de novo assembly revealed genomic architecture of Indian Mithun (Bos frontalis)
Mithun (Bos frontalis), also called gayal, is an endangered bovine species, under the tribe bovini with 2n = 58 XX chromosome complements and reared under the tropical rain forests region of India, China, Myanmar...
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Open AccessWeighting sequence variants based on their annotation increases the power of genome-wide association studies in dairy cattle
Genome-wide association studies (GWAS) are widely used to identify regions of the genome that harbor genetic determinants of quantitative traits. However, the multiple-testing burden from scanning tens of mill...
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Open AccessA splice donor variant in CCDC189 is associated with asthenospermia in Nordic Red dairy cattle
Cattle populations are highly amenable to the genetic map** of male reproductive traits because longitudinal data on ejaculate quality and dense microarray-derived genotypes are available for thousands of ar...
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Open AccessPrioritizing candidate genes for fertility in dairy cows using gene-based analysis, functional annotation and differential gene expression
An unfavorable genetic correlation between milk production and fertility makes simultaneous improvement of milk production and fertility difficult in cattle breeding. Rapid genetic improvement in milk producti...
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Open AccessDissecting closely linked association signals in combination with the mammalian phenotype database can identify candidate genes in dairy cattle
Genome-wide association studies (GWAS) have been successfully implemented in cattle research and breeding. However, moving from the associations to identify the causal variants and reveal underlying mechanisms...
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Open AccessRetraction Note: Dissecting closely linked association signals in combination with the mammalian phenotype database can identify candidate genes in dairy cattle
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Open AccessImpact of rare and low-frequency sequence variants on reliability of genomic prediction in dairy cattle
Availability of whole-genome sequence data for a large number of cattle and efficient imputation methodologies open a new opportunity to include rare and low-frequency variants (RLFV) in genomic prediction in ...
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Open AccessGenome-wide SNP profiling of worldwide goat populations reveals strong partitioning of diversity and highlights post-domestication migration routes
Goat populations that are characterized within the AdaptMap project cover a large part of the worldwide distribution of this species and provide the opportunity to assess their diversity at a global scale. We ...
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Open AccessSignatures of selection and environmental adaptation across the goat genome post-domestication
Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems an...
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Open AccessSNP markers associated with body size and pelt length in American mink (Neovison vison)
Identification of genes underlying production traits is a key aim of the mink research community. Recent availability of genomic tools have opened the possibility for faster genetic progress in mink breeding. ...
