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Article
Correction to: Aging and Mechanoadaptive Responsiveness of Bone
The author missed to include the below statement in the Acknowledgement of the original article.
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Article
Open AccessSpatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints
Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage....
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Article
Open AccessMeniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis
Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rare...
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Article
In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography
Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and lengthy scan times. Here, we report t...
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Article
Open AccessAging and Mechanoadaptive Responsiveness of Bone
Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in ...
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Article
Open AccessConditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, w...
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Protocol
Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
The techniques that are useful for applying mechanical strain to bone and bone cells are now more diverse than described in the second Edition. Their output has also increased substantially and, perhaps most i...
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Protocol
In Vivo Models of Mechanical Loading
The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled...
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Article
Open AccessTransient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to fo...
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Article
Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice
Tissue inhibitor of metalloproteinases-3 (TIMP-3) maintains a healthy extracellular matrix by regulating matrix metalloproteinases (MMP), disintegrin–metalloproteinases (ADAM), and disintegrin–metalloproteinas...
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Article
Open AccessPathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling
LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and...
