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Article
Moderate hypofractionated radiation therapy and pathologic response for soft tissue sarcomas (STS) of limbs and trunk: experience from a tertiary cancer center
Preoperative radiation therapy following by limb-sparing or conservative surgery is a standard approach for limb and trunk STS. Data supporting hypofractionated radiotherapy schedules are scarce albeit biologi...
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Article
Stereotactic body radiation therapy (SBRT) for spinal metastases: 12 years of a single center experience
To assess the clinical outcomes of patients with spine metastases treated with SBRT at our institution.
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Article
Open AccessLearning to anticipate mate presence shapes individual sex roles in the hermaphroditic pond snail, Lymnaea stagnalis
Despite being simultaneously male and female, hermaphrodites may still need to assume the male or female sexual role in a mating encounter, with the option to swap roles afterwards. For the great pond snail, Lymn...
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Article
Open AccessPatient-Reported Outcomes (PROs) in HIV Infection: Points to Consider and Challenges
The aim of this study was to reach consensus on the use of PROs (patient-reported outcome measures) in people living with HIV (PLHIV).
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Article
Open AccessEnhanced protein translocation to mammalian cells by expression of EtgA transglycosylase in a synthetic injector E. coli strain
Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host...
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Article
Open AccessSpontaneous recovery from overexpectation in an insect
In associative learning in mammals, it is widely accepted that learning is determined by the prediction error, i.e., the error between the actual reward and the reward predicted by the animal. However, it is u...
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Article
In vivo hypermutation and continuous evolution
Directed evolution has revolutionized biomolecular engineering by applying cycles of mutation, amplification and selection to genes of interest (GOIs). However, classical directed evolution methods that rely o...
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Article
Open AccessHIV-reservoir size is not affected either by HCV coinfection or by direct acting antivirals (DAAs) therapy
The role of HCV on the HIV reservoir is controversial since the reduction on HIV-DNA levels after HCV eradication with IFNα/RBV treatment seems to be the result of drugs instead of HCV clearance. We assessed w...
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Article
Open AccessIncreased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male
Low BMD (bone mineral density) has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied in young HIV-infected...
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Article
Open AccessIn vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9
In vivo mutagenesis systems accelerate directed protein evolution but often show restricted capabilities and deleterious off-site mutations on cells. To overcome these limitations, here we report an in vivo pl...
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Article
Reinforcement of schedule-induced drinking in rats by lick-contingent shortening of food delivery
Schedule-induced drinking has been a theoretical question of concern ever since it was first described more than 50 years ago. It has been classified as adjunctive behavior; that is, behavior that is induced b...
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Article
Open AccessIn situgastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli
Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the tripartite toxin complex, composed of the receptor-bindi...
