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  1. No Access

    Article

    CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

    The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymp...

    Justin Harper, Shari Gordon, Chi Ngai Chan, Hong Wang, Emily Lindemuth… in Nature Medicine (2020)

  2. No Access

    Article

    Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

    Understanding the resistance of natural hosts of simian immunodeficiency virus (SIV)—such as sooty mangabeys—to disease progression may yield insights applicable to HIV-1. In this issue, Paiardini et al. report t...

    Mirko Paiardini, Barbara Cervasi, Elane Reyes-Aviles, Luca Micci… in Nature Medicine (2011)