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    Continuous Monoclonal Antibody Production by a Composite Gel Perfusion Bioreactor in a Protein-Free Medium

    An alginate/agarose composite gel system for the immobilisation of hybridoma cells, was developed, integrating the simplicity of gelation but instability of calcium alginate and the stability, rigidity and por...

    B. Q. Shen, S. Reid, P. F. Greenfield in Animal Cell Technology: Basic & Applied Aspects (1992)