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Article
Open AccessThe ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. Human embryonic stem cel...
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Article
Open AccessAuthor Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
Induced pluripotent stem cells (iPSCs) undergo unlimited self-renewal while maintaining their potential to differentiate into post-mitotic cells with an intact proteome. As such, iPSCs suppress the aggregation...
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Article
Open AccessSomatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein home...
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Protocol
Chromosome Tracking in Fused Cells by Single Nucleotide Polymorphisms
Single nucleotide polymorphisms (SNP) refer to single-base differences in DNA sequence between individuals of the same species. In experimental setting, inbred mouse strains can easily be distinguished by thei...
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Chapter
Embryonic Stem Cells, Cardiomyoplasty, and the Risk of Teratoma Formation
Embryonic, fetal, and adult stem cells have been extensively tested in the past decade as candidates for cell replacement therapy of severe heart failure. Among them, embryonic stem (ES) cells have been regard...
