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Article
Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
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Article
Usefulness of pituitary high-resolution 3D MRI with deep-learning-based reconstruction for perioperative evaluation of pituitary adenomas
To evaluate the diagnostic value of T1-weighted 3D fast spin-echo sequence (CUBE) with deep learning-based reconstruction (DLR) for depiction of pituitary adenoma and parasellar regions on contrast-enhanced MRI.
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Article
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks were elicited, the n...
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Article
Open AccessThe impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the disease status of IPF. The clinical significance of oscillometry measur...
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Article
Formation of internal carotid artery aneurysms following gamma knife radiosurgery for pituitary adenomas: a case series and literature review
Only two aneurysm formations in the internal carotid artery after gamma knife radiosurgery (GKRS) for pituitary adenomas are reported so far. Here, out of the 482 patients who underwent GKRS for pituitary aden...
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Article
Open AccessImpact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma
The nuclear envelope (NE) is often challenged by various stresses (known as “NE stress”), leading to its dysfunction. Accumulating evidence has proven the pathological relevance of NE stress in numerous diseas...
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Article
Evaluation of cholesterol crystals in carotid plaque by dual energy computed tomography
Cholesterol crystals (CCs) in carotid plaques might be an indicator of vulnerability, although they have not been fully investigated and non-invasive methods of assessment have not been established. This study...
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Article
Open AccessHealth-related quality of life with enzalutamide versus flutamide in castration-resistant prostate cancer from the AFTERCAB study
Patient-reported outcome (PRO) measures can provide valuable information in evaluating patients’ health-related quality of life (HRQoL). Post hoc analysis of the AFTERCAB study was conducted to evaluate the HR...
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Article
Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System
The nuclear envelope (NE) separates genomic DNA from the cytoplasm and provides the molecular platforms for nucleocytoplasmic transport, higher-order chromatin organization, and physical links between the nucl...
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Article
Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation
Cleidocranial dysplasia (CCD) is a hereditary disorder associated with skeletal dysplasia and dental abnormalities. CCD arises from heterozygous loss of function mutations in the Runt-related transcription fac...
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Article
Open AccessAssociation between annual change in FEV1 and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. The decline in forced expiratory volume in one second (FEV1) is considered to be one of the...
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Article
Open AccessCorrection to: Real-world use of enzalutamide in men with nonmetastatic castration-resistant prostate cancer in Japan
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Article
Open AccessReal-world use of enzalutamide in men with nonmetastatic castration-resistant prostate cancer in Japan
The purpose of the study is to evaluate real-world effectiveness and safety of enzalutamide in men with nonmetastatic castration-resistant prostate cancer (nmCRPC) in Japan.
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Article
Open AccessUltrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonance
The COVID-19 pandemic has created urgent demand for rapid detection of the SARS-CoV-2 coronavirus. Herein, we report highly sensitive detection of SARS-CoV-2 nucleocapsid protein (N protein) using nanoparticle...
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Article
Extraction of metastasis hotspots in a whole-body bone scintigram based on bilateral asymmetry
A hotspot of bone metastatic lesion in a whole-body bone scintigram is often observed as left–right asymmetry. The purpose of this study is to present a network to evaluate bilateral difference of a whole-body...
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Article
Classification of large-scale image database of various skin diseases using deep learning
The purpose of this study was to develop a deep learning-based computer-aided diagnosis system for skin disease classification using photographic images of patients. The targets are 59 skin diseases, including...
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Article
Treatment of air leakage using the VIO soft coagulation system: a mouse pulmonary air leak model
We aimed to compare the efficacy of the VIO soft coagulation system (VSCS) for the treatment of air leaks by sealing with fibrin glue, and also assess the histological alterations that occur after soft coagula...
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Article
Open AccessOASIS/CREB3L1 is a factor that responds to nuclear envelope stress
The nuclear envelope (NE) safeguards the genome and is pivotal for regulating genome activity as the structural scaffold of higher-order chromatin organization. NE had been thought as the stable during the int...
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Article
Open AccessA 3D analysis of growth trajectory and integration during early human prenatal facial growth
Significant shape changes in the human facial skeleton occur in the early prenatal period, and understanding this process is critical for studying a myriad of congenital facial anomalies. However, quantifying ...
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Chapter and Conference Paper
Statistical Modeling of Pulmonary Vasculatures with Topological Priors in CT Volumes
A statistical appearance model of blood vessels based on variational autoencoder (VAE) is well adapted to image intensity variations. However, images reconstructed with such a statistical model may have topolo...
