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Article
Open AccessMethods and tools for handling, transportation, weighing, and pelletization applied to the initial analysis of volatile components in the Hayabusa2 samples
The Hayabusa2 spacecraft succeeded in sampling and returning materials from the C-type, near-Earth asteroid (162173) Ryugu. As part of the Hayabusa2 Initial Analyses, chemical and isotopic compositions of vola...
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Article
Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants
Staphylococcal scalded skin syndrome (SSSS) demonstrates dermal symptoms due to exfoliative toxin (ET) A or ETB produced by Staphylococcus aureus. We examined the association between anti-ETA antibodies and SSSS ...
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Protocol
Electroporation of Dissociated Hippocampal Neurons
Consistent and efficient gene transfer into postmitotic neurons is desirable for the study of neurons. Recent refinement of cell culturing techniques has enabled us to prepare various types of neurons in disso...
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Article
Open AccessSynergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells
A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation o...
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Article
Open AccessExtremely low flow tracheal gas insufflation of helium-oxygen mixture improves gas exchange in a rabbit model of piston-type high-frequency oscillatory ventilation
The purpose of this study was to show the effects of the tracheal gas insufflation (TGI) technique on gas exchange using helium-oxygen mixtures during high-frequency oscillatory ventilation (HFOV). We hypothes...
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Article
Open AccessPitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/dbobese mice
Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin level...
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Article
PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B
Reversible histone methylation and demethylation are highly regulated processes that are crucial for chromatin reorganization and regulation of gene transcription in response to extracellular conditions. Howev...
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Article
Study of device malfunctions in patients with implantable ventricular assist devices living at home
Clinical introduction of implantable ventricular assist devices (VADs) is expected to encourage VAD therapy for severe heart failure patients in Japan. Since even minor device malfunctions can lead to serious ...
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Article
Vitamin D3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns
Bactericidal activities of neutrophils occur by two distinctive mechanisms that are oxygen-dependent and -independent. Human cathelicidin antimicrobial peptide 18 (hCAP18), also known as LL-37/FALL-39, is a ne...
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Article
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
The dioxins, a family of halogenated organic compounds formed as by-products of various industrial processes, are toxic because of their interaction with signalling pathways linked to steroid hormone function....
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Chapter and Conference Paper
An Implantable Probe for Chronic Observation of Microcirculation
Whether the pulsatile flow is essential for living body or not is long-term controversial point between circulatory physiologist and artificial heart researchers. Especially, since an axial flow pump, continuo...
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Article
ISS experiments for the clarification of boiling and two-phase flow in microgravity and for the development of high-performance space cold plates
Inflow boiling, gravity effects on the distribution of both phases are observed in a heated tube and heat transfer coefficients due to two-phase forced convection is deteriorated in microgravity. In narrow cha...
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Article
β-Amyloid prevents excitotoxicity via recruitment of glial glutamate transporters
Amyloid β-protein (Aβ), a putative pathogenic endotoxin involved in Alzheimer's disease, induces redistribution of glutamate transporters in astrocytes and promotes their pump activity. Because the transporter...
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Article
Different Ca2+ dynamics between isolated hippocampal pyramidal cells and dentate granule cells
The hippocampal formation contains a variety of neuronal types. The principal neurons are granule cells in the dentate gyrus and pyramidal cells in Ammon's horn. These two neuron types show distinct cell morph...
