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Article
Open AccessHsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
Acquisition of mutations is central to evolution; however, the detrimental effects of most mutations on protein folding and stability limit protein evolvability. Molecular chaperones, which suppress aggregatio...
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Article
Mutational and fitness landscapes of an RNA virus revealed through population sequencing
A new approach to accurately determine mutation frequencies with RNA virus populations called circular sequencing (CirSeq) has been developed; a study of the genetic composition of populations of poliovirus sh...
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Article
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes
Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo. AC...