-
Article
Open AccessDefective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
Arthropod-borne viruses pose a major threat to global public health. Thus, innovative strategies for their control and prevention are urgently needed. Here, we exploit the natural capacity of viruses to genera...
-
Article
Open AccessPoliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
RNA viruses, such as poliovirus, have a great evolutionary capacity, allowing them to quickly adapt and overcome challenges encountered during infection. Here we show that poliovirus infection in immune-compet...
-
Article
Correction: Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Nature Communications 5: Article number: 3966 (2014); Published online: 3 June 2014; Updated: 12 Aug 2015. In Fig. 2 of this Article, the CLOCK protein sequence of the blind mole rat (Spalax) was inadvertently...
-
Article
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from pr...
-
Article
Mutational and fitness landscapes of an RNA virus revealed through population sequencing
A new approach to accurately determine mutation frequencies with RNA virus populations called circular sequencing (CirSeq) has been developed; a study of the genetic composition of populations of poliovirus sh...
-
Article
Tandem repeats on an eco-geographical scale: outcomes from the genome of Aegilops speltoides
The chromosomal pattern of tandem repeat fractions of repetitive DNA is one of the most important characteristics of a species. In the present research, we aimed to detect and evaluate the level of intraspecif...
-
Article
Open AccessGenome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments
The pattern-forming bacterium Paenibacillus vortex is notable for its advanced social behavior, which is reflected in development of colonies with highly intricate architectures. Prior to this study, only two oth...
-
Article
Open AccessTransposable elements in a marginal plant population: temporal fluctuations provide new insights into genome evolution of wild diploid wheat
How new forms arise in nature has engaged evolutionary biologists since Darwin's seminal treatise on the origin of species. Transposable elements (TEs) may be among the most important internal sources for intr...
-
Article
Molecular analysis of transitional cell carcinoma using cDNA microarray
The incidence of transitional cell carcinoma (TCC), the fourth most common neoplasm diagnosed in men, is rising. Despite the development of several noninvasive diagnostic tests, none have gained full recogniti...
