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  1. Article

    Open Access

    Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease

    IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obli...

    Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata… in Arthritis Research & Therapy (2024)

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  2. Article

    Open Access

    Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake

    Epithelial cells control a variety of immune cells by secreting cytokines to maintain tissue homeostasis on mucosal surfaces. Regulatory T (Treg) cells are essential for immune homeostasis and for preventing t...

    Tadamichi Kasuya, Shigeru Tanaka, Jun Tamura, Keishi Etori… in Scientific Reports (2023)

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    Article

    Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells

    Allergic asthma that is caused by inhalation of house dust mites (HDMs) is mainly mediated by Th2 cells. Recently, the roles of Sox (SRY-related high-mobility-group (HMG)-box) family members in various immune ...

    Ken-Ichi Suehiro, Akira Suto, Kensuke Suga… in Cellular & Molecular Immunology (2021)

  4. No Access

    Article

    An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development

    Classical type 1 dendritic cells (cDC1s) are required for antiviral and antitumor immunity, which necessitates an understanding of their development. Development of the cDC1 progenitor requires an E-protein-de...

    Prachi Bagadia, **ao Huang, Tian-Tian Liu, Vivek Durai… in Nature Immunology (2019)

  5. No Access

    Article

    Cryptic activation of an Irf8 enhancer governs cDC1 fate specification

    Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction ar...

    Vivek Durai, Prachi Bagadia, Jeffrey M. Granja, Ansuman T. Satpathy… in Nature Immunology (2019)

  6. No Access

    Article

    Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF–IRF4 transcription factor complex

    Murphy and colleagues show that the transcription-factor complex BATF-IRF4, which recognizes AICE motifs within gene enhancers, is sensitive to TCR signaling strength and identify distinct gene targets that re...

    Arifumi Iwata, Vivek Durai, Roxane Tussiwand, Carlos G Briseño… in Nature Immunology (2017)

  7. No Access

    Article

    Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor

    The transcription factors Batf3 and IRF8 are required for the development of CD8α+ conventional dendritic cells (cDCs). Murphy and colleagues characterize the Batf3-IRF8 interactions that allow differentiation to...

    Gary E Grajales-Reyes, Arifumi Iwata, Jörn Albring, **aodi Wu… in Nature Immunology (2015)

  8. No Access

    Article

    Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients

    A significant proportion of patients with connective tissue disease (CTD) have gastric esophageal reflux disease (GERD) symptoms despite receiving proton pump inhibitors (PPIs). Although pre-meal administratio...

    Arifumi Iwata, Kei Ikeda, Koichi Hirose, Hiroaki Takatori… in Modern Rheumatology (2013)