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Article
Concentration-dependent bacterial cellulose patches: a strategy for modulating the drug release beyond the modifications of the native cellulose hydrogel
Considering the increasing interest in the need-specific drug release profiles in transdermal patches, the understanding of the complex relationship between the release kinetics and factors like the drug loadi...
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Article
Open AccessRoad networks and socio-demographic factors to explore COVID-19 infection during its different waves
The COVID-19 pandemic triggered an unprecedented level of restrictive measures globally. Most countries resorted to lockdowns at some point to buy the much-needed time for flattening the curve and scaling up v...
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Article
Open AccessEvaluation of loci to predict ear morphology using two SNaPshot assays
Human ear morphology prediction with SNP-based genotypes is growing in forensic DNA phenoty** and is scarcely explored in Pakistan as a part of EVCs (externally visible characteristics). The ear morphology p...
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Article
Open AccessComplete chloroplast genome sequencing and comparative analysis of threatened dragon trees Dracaena serrulata and Dracaena cinnabari
Dracaena (Asparagaceae family) tree is famous for producing "dragon blood"—a bioactive red-colored resin. Despite its long history of use in traditional medicine, little knowledge exists on the genomic architectu...
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Article
Spectroscopic and molecular docking investigation of the binding of a bioactive mercaptobenzimidazole-functionalized Schiff base to human serum albumin
This study was conducted to examine the binding of a newly synthesized Schiff base derived from 2-hydroxy-1-naphthaldehyde and 5-amino-2-mercaptobenzimidazole with human serum albumin (HSA) employing various b...
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Article
Open AccessTranscriptomic analysis of Dubas bug (Ommatissus lybicus Bergevin) infestation to Date Palm
Date palm (Phoenix dactylifera L.) and its fruit possess sociocultural, health and economic importance in Middle East. The date palm plantations are prone to Dubas bug (DB; Ommatissus lybicus DeBergevin; Homopter...
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Article
Open AccessExpanded inverted repeat region with large scale inversion in the first complete plastid genome sequence of Plantago ovata
Plantago ovata (Plantaginaceae) is an economically and medicinally important species, however, least is known about its genomics and evolution. Here, we report the first complete plastome genome of P. ovata and c...
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Chapter and Conference Paper
Understanding the Progression of Congestive Heart Failure of Type 2 Diabetes Patient Using Disease Network and Hospital Claim Data
Chronic diseases have increasingly become common and caused most of the burden of ill health in most countries. They have large impacts on quality of life, social and economic conditions. These diseases bring ...
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Article
Open AccessComparing different supervised machine learning algorithms for disease prediction
Supervised machine learning algorithms have been a dominant method in the data mining field. Disease prediction using health data has recently shown a potential application area for these methods. This study a...
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Article
Few research fields play major role in interdisciplinary grant success
Interdisciplinary research is vital in addressing complex real-world problems. To understand how the scientific workforce is being engaged in the interdisciplinary research, it is important to track the involv...
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Article
Identification of suitable internal control genes for transcriptional studies in Eleusine coracana under different abiotic stress conditions
Finger millet [Eleusine coracana (L.) Gaertn] is an excellent food and forage crop of arid and semiarid areas in Africa and Asia. It is well adapted to drought, heat, high salinity, poor soil fertility and low pH...
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Article
Open AccessDecreased suicide rates in recent antidepressant clinical trials
The last systematic analysis of suicidality in antidepressant clinical trials submitted for approval by the US Food and Drug Administration was in 2000. Given the attention to suicide and antidepressants in th...
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Chapter
Antioxidant and Anti-inflammatory Action of Thymoquinone
Antioxidant and anti-inflammatory action of thymoquinone (TQ) may be utilized in the treatment of inflammatory diseases such as prostatitis, neuropsychiatric, mucositis, etc. TQ has been shown to have potentia...
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Article
Open AccessAdjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study
The objective of this study was to investigate the efficacy and safety of adjunctive lanicemine (NMDA channel blocker) in the treatment of major depressive disorder (MDD) over 12 weeks. This phase IIb, randomi...
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Chapter
Bacillus spp.: A Prolific Siderophore Producer
Bacillus species comprises of several hundred species and is characterized as non-spore- or endospore-forming, straight or slightly curved Gram-positive rods, which may turn Gram-negative with age, and single or...
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Article
A topological framework to explore longitudinal social networks
Longitudinal networks evolve over time through the creation and/or deletion of links among a set of actors (e.g., individuals or organizations). A longitudinal network can be viewed as a single static network ...
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Article
Open AccessMagnitude of change with antidepressants and placebo in antidepressant clinical trials using structured, taped and appraised rater interviews (SIGMA-RAPS) compared to trials using traditional semi-structured interviews
Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiota** and Rater Applied Performance Scale (RAPS) appraisal have b...
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Article
Life Threatening Complication of Sore Throat: Lemierre’s Syndrome
The authors report a case of previously healthy toddler who presented with acute sore throat that led to bacteremia, septic shock, disseminated intravascular coagulopathy, encephalopathy and pleural effusion. ...
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Article
Association of Cadmium and Lead with Antioxidant Status and Incidence of Benign Prostatic Hyperplasia in Patients of Western India
The association of cadmium (Cd) and lead (Pb) in the pathophysiology and progression of benign prostate hyperplasia (BPH) has been evaluated in an epidemiological study with 116 BPH patients of the western par...
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Chapter
Model for Quantum Confinement in Nanowires and the Application of This Model to the Study of Carrier Mobility in Nanowire FinFETs
FinFETs represent exciting new technology. Nanowire FinFETs are more promising than the bulk-silicon FinFETs. As they have the gate capacitance in closer proximity to the whole of the channel, they control the...
