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Article
Open AccessStrategies and governance to reduce health inequalities: evidences from a cross-European survey
The main objective of the paper is to identify the governance system related to policies to reduce health inequalities in the European regions. Considering the Action Spectrum of inequalities and the check lis...
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Article
Open AccessPhase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial
Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in ...
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Article
Open AccessTrends in socioeconomic inequalities in mortality in small areas of 33 Spanish cities
In Spain, several ecological studies have analyzed trends in socioeconomic inequalities in mortality from all causes in urban areas over time. However, the results of these studies are quite heterogeneous find...
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Article
Open AccessTrends in socioeconomic inequalities in preventable mortality in urban areas of 33 Spanish cities, 1996–2007 (MEDEA project)
Preventable mortality is a good indicator of possible problems to be investigated in the primary prevention chain, making it also a useful tool with which to evaluate health policies particularly public health...
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Article
Trends in Socioeconomic Inequalities in Ischemic Heart Disease Mortality in Small Areas of Nine Spanish Cities from 1996 to 2007 Using Smoothed ANOVA
The aim of this study was to analyze the evolution of socioeconomic inequalities in mortality due to ischemic heart diseases (IHD) in the census tracts of nine Spanish cities between the periods 1996–2001 and ...
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Article
Open AccessDo socioeconomic inequalities in mortality vary between different Spanish cities? a pooled cross-sectional analysis
The relationship between deprivation and mortality in urban settings is well established. This relationship has been found for several causes of death in Spanish cities in independent analyses (the MEDEA proje...
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Article
Open AccessPhase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma
The effect of the addition of fotemustine and/or interferon (IFN) to standard therapy with dacarbazine alone in patients with advanced malignant melanoma was investigated in a multicenter, randomized 2x2 facto...
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Article
Open AccessErratum to: Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities
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Article
Open AccessCancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities
Intra-urban inequalities in mortality have been infrequently analysed in European contexts. The aim of the present study was to analyse patterns of cancer mortality and their relationship with socioeconomic de...
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Article
Open AccessRegulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-α 2b treatment
High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of ...
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Article
Open AccessThe role of spectrophotometry in the diagnosis of melanoma
Spectrophotometry (SPT) could represent a promising technique for the diagnosis of cutaneous melanoma (CM) at earlier stages of the disease. Starting from our experience, we further assessed the role of SPT in...
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Article
Open AccessLaparoscopic cholecystectomy for melanoma metastatic to the gallbladder: is it an adequate surgical procedure? Report of a case and review of the literature
Only 2% to 4% of patients with melanoma will be diagnosed with gastrointestinal metastasis during the course of their disease. The most common sites of gastrointestinal metastases from melanoma include the sma...
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Article
Open AccessSerial detection of circulating tumour cells by reverse transcriptase-polymerase chain reaction assays is a marker for poor outcome in patients with malignant melanoma
Detection of circulating malignant cells (CMCs) through a reverse transcriptase-polymerase chain reaction (RT-PCR) assay seems to be a demonstration of systemic disease. We here evaluated the prognostic role o...
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Article
Socio-Economic Level, Farming Activities and Risk of Cancer in Small Areas of Southern Spain
An ecological design was used to study the relationship between cancer incidence and both socio-economic and environmental features in Southern Spain. Twenty-four sites and 26,380 cases diagnosed in 1985–1996 ...
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Article
Weekly paclitaxel-cisplatin administration with G-CSF support in advanced breast cancer. A phase II study
Purpose: In a previous phase I study we found the MTDs of paclitaxel and cisplatin when given together weekly, with or without G-CSF support, in patients with advanced solid tumors. The present study was conducte...
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Article
Treatment of resistant non-Hodgkin’s lymphomas with cisplatin, etoposide, and bleomycin
A combination of cisplatin (60 mg/m2 i.v. on day 1), etoposide (100 mg/m2 i.v. on days 1 – 3) and bleomycin (15 mg i. v. on days 1 and 8) (PEB regimen) was given every 4 weeks as salvage therapy in 10 refractory ...
