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Article
Open AccessActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well documented th...
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Reference Work Entry In depth
Methods to Study Metagenomics
Metagenomic profiling of human fecal samples has long uncovered the importance of the microbiota in human health and disease. In recent years, metagenomic studies have demonstrated that the microbes that inhab...
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Living Reference Work Entry In depth
Methods to Study Metagenomics
Metagenomic profiling of human fecal samples has long uncovered the importance of the microbiota in human health and disease. In recent years, metagenomic studies have demonstrated that the microbes that inhab...
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Article
How Modulations of the Gut Microbiota May Help in Preventing or Treating Parasitic Diseases
Due to the combined effects of international travel, climate change, and globalization, clinicians in Southern Europe are seeing a re-emergence of parasitic infections once thought to have been eradicated, whi...
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Article
Open AccessWAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans
Impaired mitochondrial energy metabolism contributes to a wide range of pathologic conditions, including neurodegenerative diseases. Mitochondrial apoptosis-inducing factor (AIF) is required for the correct ma...
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Article
Open AccessThe SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function
Chromatin remodelers have emerged as prominent regulators of epigenetic processes and potential drivers of various human pathologies. The multi-subunit chromatin-remodeling SWI/SNF complex determines gene expr...
