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Open AccessEarly combination therapy of COVID-19 in high-risk patients
Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as rec...
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Open AccessTotal marrow irradiation versus total body irradiation using intensity-modulated helical tomotherapy
Total body irradiation (TBI) is often a component of the conditioning regimen prior to hematopoietic stem cell transplantation in patients with hematological malignancies. However, total marrow irradiation (TM...
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Open AccessWhole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics
Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal...
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Open AccessTwo cases of EBV infection preceding lymphoma
Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for develo** lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in...
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Open AccessBlastic plasmacytoid dendritic-cell neoplasia: a challenging case report
Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an extremely rare disease that originates from dendritic cells and is associated with a poor overall survival (OS). Diagnostic and therapeutic standards ...
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Open AccessElotuzumab spares dendritic cell integrity and functionality
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The role of checkpoint blockade after allogeneic stem cell transplantation in diseases other than Hodgkin’s Lymphoma
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment option for many malignant high-risk hematological diseases. The Graft-vs.-Tumor (GvT) effect is the major hallmark ...
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Living Reference Work Entry In depth
Nierenzellkarzinom
Das Nierenzellkarzinom ist ein vom Nierenparenchym ausgehender maligner Tumor, der ca. 2–3 % aller bösartigen Erkrankungen des Erwachsenen ausmacht. Es ist im Frühstadium symptomarm bzw. symptomlos. Aufgrund d...