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  1. Article

    Open Access

    The PI3Kδ inhibitor idelalisib impairs the function of human dendritic cells

    The PI3Kδ-inhibitor Idelalisib is approved for the treatment of Non-Hodgkin lymphoma. However, its use has been decreased within the last years due to deleterious infections such as cytomegalovirus and pneumoc...

    Christiane Braun, Sebastian Schlaweck… in Cancer Immunology, Immunotherapy (2021)

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    Article

    Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

    Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC supp...

    Tobias Baumann, Andreas Dunkel, Christian Schmid, Sabine Schmitt… in Nature Immunology (2020)

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    Article

    The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib

    Increased numbers of immunosuppressive myeloid derived suppressor cells (MDSCs) correlate with a poor prognosis in cancer patients. Tyrosine kinase inhibitors (TKIs) are used as standard therapy for the treat...

    Annkristin Heine, Judith Schilling, Barbara Grünwald… in Cancer Immunology, Immunotherapy (2016)

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    Article

    Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides

    Imatinib (IM) has been described to modulate the function of dendritic cells and T lymphocytes and to affect the expression of antigen in CML cells. In our study, we investigated the effect of the tyrosine kin...

    Stefanie Andrea Erika Held, Katharina Maria Duchardt… in Cancer Immunology, Immunotherapy (2013)

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    Article

    Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells

    Advances in tumor immunology and Identification of tumor-associated antigens (TAAs) provide a basis for the development of novel immunotherapies to treat malignant diseases. In order to identify novel TAAs, we...

    Frank Grünebach, Stefanie Erndt, Maik Häntschel… in Cancer Immunology, Immunotherapy (2008)