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Article
Open AccessOcrelizumab exposure in relapsing–remitting multiple sclerosis: 10-year analysis of the phase 2 randomized clinical trial and its extension
Open-label extension (OLE) studies help inform long-term safety and efficacy of disease-modifying therapies in multiple sclerosis (MS). We report exploratory analyses from a phase 2 trial on the longest follow...
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Article
Assessment of Drug–Drug Interactions between Taspoglutide, a Glucagon-Like Peptide-1 Agonist, and Drugs Commonly Used in Type 2 Diabetes Mellitus: Results of Five Phase I Trials
Taspoglutide, a glucagon-like peptide-1 agonist, like native glucagon-like peptide-1, delays gastric emptying time and prolongs intestinal transit time, which may alter the pharmacokinetics of concomitantly ad...
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Article
Individual behavioural variability of an ecological generalist: activity patterns and local movements of Mallards Anas platyrhynchos in winter
Common and widespread species often show a large variability in behaviour and habitat use. Such variability at the species level may result from individuals themselves being very variable or, alternatively, va...
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Article
Does optimal foraging theory explain why suburban Florida scrub-jays (Aphelocoma coerulescens) feed their young human-provided food?
Optimal foraging theory assumes that a forager can adequately assess the quality of its prey and predicts that parents feed their young low-quality foods only when suffering unpredicted reductions in their abi...
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Article
Gene Regulation by Transmembrane Signaling
Studies of the ferric citrate transport genes in Escherichia coli K-12 have revealed a novel type of transcriptional regulation. The inducer, ferric citrate, binds to an outer membrane protein and must not be tra...
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Article
Gene Regulation by Transmembrane Signaling
Studies of the ferric citrate transport genes in Escherichia coli K-12 have revealed a novel type of transcriptional regulation. The inducer, ferric citrate, binds to an outer membrane protein and must not be tra...