-
Article
Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether anal...
-
Article
Association of admission temperature and death or adverse neurodevelopmental outcomes in extremely low-gestational age neonates
Preterm infants are at higher risk of develo** hypothermia and complications from cold stress, resulting in high mortality and short-term morbidity. Our objective is to evaluate the association between admis...
-
Article
Open AccessMAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP)—implementation of a national guideline in Canada
Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32–34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to preven...
-
Article
Open AccessTiming of delivery in a high-risk obstetric population: a clinical prediction model
The efficacy of antenatal corticosteroid treatment for women with threatened preterm birth depends on timely administration within 7 days before delivery. We modelled the probability of delivery within 7 days ...
-
Chapter and Conference Paper
Prediction of Brain Network Age and Factors of Delayed Maturation in Very Preterm Infants
Babies born very preterm (<32 weeks postmenstral age), are at a high risk of having delayed or altered neurodevelopment. Diffusion MRI (dMRI) is a non-invasive neuroimaging modality that allows for early analy...
-
Article
Early postnatal docosahexaenoic acid levels and improved preterm brain development
Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for the develo** brain. This study examined the association between postnatal fatty acid levels and measures of brain injury and de...
-
Chapter and Conference Paper
Predictive Subnetwork Extraction with Structural Priors for Infant Connectomes
We present a new method to identify anatomical subnetworks of the human white matter connectome that are predictive of neurodevelopmental outcomes. We employ our method on a dataset of 168 preterm infant conne...
-
Article
Open AccessMagnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada
Administration of magnesium sulphate (MgSO4) to women with imminent preterm birth at <34 weeks is an evidence-based antenatal neuroprotective strategy to prevent cerebral palsy. Although a Society of Obstetrician...
-
Chapter and Conference Paper
Prediction of Motor Function in Very Preterm Infants Using Connectome Features and Local Synthetic Instances
We propose a method to identify preterm infants at highest risk of adverse motor function (identified at 18 months of age) using connectome features from a diffusion tensor image (DTI) acquired shortly after b...
-
Article
Open AccessMagnesium sulphate for fetal neuroprotection: a cost-effectiveness analysis
The aim of this study was to assess the cost-effectiveness of administering magnesium sulphate to patients in whom preterm birth at < 32+0 weeks gestation is either imminent or threatened for the purpose of fetal...
-
Article
Outcomes of Infants ≤25 Weeks Gestation in a Large Canadian Cohort
-
Article
Actuarial Survival in a Large Canadian Cohort of Preterm and Very Low Birthweight Infants: No Gender Effects Beyond 24 Weeks Gestation
-
Article
The Incidence of Diagnosed Intraventricular Hemorrhage in Canadian Neonatal Intensive Care Units
-
Article
Benchmarks for Nosocomial Infection (NI) Rates in Neonatal Intensive Care Units (NICUs)
-
Article
Variations in Treatment Decisions and Outcomes of Infants ≤25 Weeks Gestation: Evidence from Canada
-
Article
Mortality Variations and Illness Severity (SNAP-II) in Canadian NICUs