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Article
Open AccessAbsence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma
The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activi...
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Article
Open AccessPolysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas
The aim of the study was to assess the localization of Polysialic acid (polySia) and Neural cell adhesion molecule (NCAM) in grade I–IV astrocytomas by confocal microscopy, and also to clarify and compare thei...
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Chapter
Endosialidases: Versatile Tools for the Study of Polysialic Acid
Polysialic acid is an α2,8-linked N-acetylneuraminic acid polymer found on the surface of both bacterial and eukaryotic cells. Endosialidases are bacteriophage-borne glycosyl hydrolases that specifically cleave p...
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Article
Open AccessHuman Metaplastic Breast Carcinoma and Decorin
Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracel...
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Article
Open AccessReceptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
Receptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or a...
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Article
Open AccessCombined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia
The return of blood flow to ischemic heart after myocardial infarction causes ischemia–reperfusion injury. There is a clinical need for novel therapeutic targets to treat myocardial ischemia–reperfusion injury...
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Article
Open AccessAn extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain...
