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Article
Open AccessAortic elastic fiber degeneration during acute type a aortic dissection and reverse aortic remodeling
Progression of proximal or distal aortic dilatation is defined as reverse aortic remodeling after surgery for acute type A aortic dissection (ATAAD) that may be dependent on aortic wall degeneration.
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Article
Open AccessHistopathology reveals concealed aortic valve inflammation
The extent of aortic valve inflammation in patients undergoing aortic valve replacement (AVR) is unsettled. The significance of aortic valve histopathology in patients undergoing AVR is undetermined.
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Article
Open AccessAscending aortic wall degeneration in patients with bicuspid versus tricuspid aortic valve
The magnitude of ascending aortic degeneration in patients with bicuspid aortic valves (BAV) is controversial.
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Article
Open AccessEvaluation Challenges in the Validation of B7-H3 as Oral Tongue Cancer Prognosticator
B7-H3 was the only molecule identified with prognostic potential from a recent systematic review of the prognostic value of immune checkpoints in oral cancer. We aimed to validate this finding in a multicenter...
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Article
Open AccessClinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting...
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Article
Open AccessPerformance of Finnish biobanks in nationwide pulmonary carcinoid tumour research
Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be...
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Article
Open AccessEndothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency
We studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA) components in adenine-induced chronic renal insufficiency (CRI).
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Article
High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma
Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymph...
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Article
An automated gland segmentation and classification method in prostate biopsies: an image source-independent approach
The aim of this paper is to introduce an image source-independent automated method for segmentation and classification of prostate glands. This research focuses on light microscopic images of the samples from ...
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Article
Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding
Peptic ulcer bleeding (PUB) is a major cause of upper gastrointestinal bleeding. The effect of omeprazole on mucosal repair is unknown.
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Open AccessBronchoalveolar lavage in infants with recurrent lower respiratory symptoms
Few data are available about the inflammatory cytokine profile of bronchoalveolar lavage (BAL) from young children with frequent wheeze. The first aim was to investigate the BAL cellular and cytokine profiles ...
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Article
Open AccessPolysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas
The aim of the study was to assess the localization of Polysialic acid (polySia) and Neural cell adhesion molecule (NCAM) in grade I–IV astrocytomas by confocal microscopy, and also to clarify and compare thei...
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Article
CIP2A expression and prognostic role in patients with esophageal adenocarcinoma
CIP2A is overexpressed in many cancers, including esophageal squamous cell carcinoma. The regulation of c-MYC and CIP2A expression is characterized by a positive feedback mechanism facilitating the expression ...
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Article
Open AccessComplement activation in astrocytomas: deposition of C4d and patient outcome
C4d is a cleavage product of complement component C4 and is considered to serve as a marker for the site of complement activation. In this study C4d staining of grade I-IV astrocytic tumors was studied to expl...
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Article
Open AccessIndoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated.
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Article
Mucosal expression of p21, p27, p53, Bcl-2, and bax after small bowel resection and autotransplantation in pigs
Massive small bowel resection increases ileal villus height as part of normal adaptation. However, despite no gut loss, autotransplantation of the entire small intestine also increases ileal villus height. Our...
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Article
Structural Signaling Regulates Inflammation-Induced Enhanced Restitution and Increased Mib-1 and Bax-Indexes After Superficial Injury in Isolated Guinea Pig Gastric Mucosa
Several growth factors and cytokines are involved in regulation of the immediate repair of gastrointestinal mucosa, a process also called restitution. Few data exist on the effect of inflammation on this proce...
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Article
Effects of ileum transplantation and chronic rejection on absorption and synthesis of cholesterol in pigs
We investigated the effects of ileum allotransplantation and chronic graft rejection on the synthesis and absorption of cholesterol. Twenty pigs underwent intestinal transection or ileum transplantation, in wh...
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Article
Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions
The expression of Cox-2 protein was studied by immunohistochemistry in normal oral mucosa and in mucosa with various lesions of oral leukoplakia, including hyperplasia and dysplasia of squamous epithelium and...
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Article
Effects of Extrinsic Denervation With or Without Ischemia–Reperfusion Injury on Constitutional Mucosal Characteristics in Porcine Jejunoileum
We investigated the effects of jejunoileal denervation with or without ischemia–reperfusion on mucosal characteristics and small intestinal structure. Growing pigs underwent sham laparotomy, jejunal transectio...
