16 Result(s)
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Article
Open AccessThe prognostic and potentially immunomodulatory role of cartilage oligomeric matrix protein in patients with gastric and esophageal adenocarcinoma
Cartilage oligomeric matrix protein (COMP) is a novel regulator of the tumor microenvironment. Studies in colon cancer and pancreatobiliary adenocarcinoma have revealed COMP expression to be associated with de...
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Article
C3 glomerulopathy — understanding a rare complement-driven renal disease
The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement ...
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Open AccessPlasma C4d as marker for lupus nephritis in systemic lupus erythematosus
In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE).
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The complement system as a potential therapeutic target in rheumatic disease
The complement system provides essential protection against infections but also contributes to the severity of autoimmune diseases
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Article
Open AccessThe human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secr...
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Article
Open AccessAnalysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis
The complement system has been implicated in pathogenesis of systemic sclerosis (SSc). The goal of the present study was to evaluate improved complement biomarkers in SSc.
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Open AccessThe complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
The complement system is suggested to be involved in the pathogenesis of osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by inducing proteases. The association between comp...
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Open AccessA subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources
Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since th...
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Article
Local expression of complement factor I in breast cancer cells correlates with poor survival and recurrence
Tumor cells often evade killing by the complement system by overexpressing membrane-bound complement inhibitors. However, production of soluble complement inhibitors in cells other than hepatocytes was rarely ...
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Open AccessCartilage oligomeric matrix protein-induced complement activation in systemic sclerosis
Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus....
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Article
Killing of CLL and NHL cells by rituximab and ofatumumab under limited availability of complement
Rituximab and ofatumumab are anti-CD20 antibodies applicable to treatment for non-Hodgkin’s lymphoma and chronic lymphocytic leukemia (CLL). Effectiveness of both immunotherapeutics may depend on exhaustible c...
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Article
Open AccessDegradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus
The ability to degrade neutrophil extracellular traps (NETs) is reduced in a subset of patients with systemic lupus erythematosus (SLE). NETs consist of chromatin covered with antimicrobial enzymes and are nor...
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Article
Open AccessFactor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome
Complement activation is involved in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atypical hemolytic uremic syndrome (aHUS). Autoantibodies to complement inhibitor factor H (FH), particula...
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Open AccessSerum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment
Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP ac...
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Open AccessMutations in genes encoding complement inhibitors CD46 and CFHaffect the age at nephritis onset in patients with systemic lupus erythematosus
Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemol...
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Hypoxia increases susceptibility of non-small cell lung cancer cells to complement attack
The complement system can be specifically targeted to tumor cells due to molecular changes on their surfaces that are recognized by complement directly or via naturally occurring antibodies. However, tumor cel...
