4 Result(s)
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Nikolina Papac-Milicevic
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Article
Open AccessMutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet
Obesity is a modifiable risk factor in cancer development, especially for gastrointestinal cancer. While the etiology of colorectal cancer is well characterized by the adenoma-carcinoma sequence, it remains un...
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Article
Open AccessFactor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease
Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that ...
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Article
Open AccessThe human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secr...
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Article
Innate sensing of oxidation-specific epitopes in health and disease
Oxidative stress results in the oxidative damage of membrane lipids, leading to the formation of neo-self epitopes, which are known as oxidation-specific epito...
