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Protocol
Microsatellite Instability: An Indirect Assay to Detect Defects in the Cellular Mismatch Repair Machinery
The DNA mismatch repair (MMR) pathway plays a prominent role in the correction of errors made during DNA replication and genetic recombination and in the repair of small deletions and loops in DNA. Mismatched ...
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Article
Human mtDNA hypervariable regions, HVR I and II, hint at deep common maternal founder and subsequent maternal gene flow in Indian population groups
We have analysed the hypervariable regions (HVR I and II) of human mitochondrial DNA (mtDNA) in individuals from Uttar Pradesh (UP), Bihar (BI) and Punjab (PUNJ), belonging to the Indo-European linguistic grou...
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Article
Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer
Interferon (IFN)-γ is an important Th1 cytokine, which plays a role in immune surveillance and anti-tumor activity. A case-control study involving 54 sporadic breast cancer patients and 144 healthy controls wa...
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Protocol
Gel-Based Nonradioactive Single-Strand Conformational Polymorphism and Mutation Detection
Single-strand conformation polymorphism (SSCP) for screening mutations/single-nucleotide polymorphisms (SNPs) is a simple, cost-effective technique, saving an expensive exercise of sequencing each and every PC...
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Article
Genetic affinity among five different population groups in India reflecting a Y-chromosome gene flow
Four binary polymorphisms and four multiallelic short tandem repeat (STR) loci from the nonrecombining region of the human Y-chromosome were typed in different Indian population groups from Uttar Pradeh (UP), ...
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Protocol
Microsatellite Instability
The DNA mismatch repair (MMR) pathway plays a prominent role in the correction of errors made during DNA replication and genetic recombination and in the repair of small deletions and loops in DNA. Mismatched ...
