57 Result(s)

Article

Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis

To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.

Tianxiang Fan, Shibo Chen, Muhui Zeng, Jia Li… in Arthritis Research & Therapy (2022)

Article

Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials

There is some evidence that corticosteroids may have a beneficial effect in hand osteoarthritis. We examined the efficacy of corticosteroids on symptoms and structural outcomes in hand osteoarthritis.

Mahnuma Mahfuz Estee, Flavia M. Cicuttini, Matthew J. Page… in BMC Musculoskeletal Disorders (2022)

Article

Topical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial

Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies. Emerging evidence suggests the role of local inflammation in causing pain in hand osteoarthritis. Cortico...

Yuanyuan Wang, Sultana Monira Hussain, Desmond Gan… in BMC Musculoskeletal Disorders (2021)

Article

METHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritis with Synovitis: study protocol for a randomised controlled trial

Hand osteoarthritis is a common and disabling problem without effective therapies. Accumulating evidence suggests the role of local inflammation in causing pain and structural progression in hand osteoarthriti...

Yuanyuan Wang, Andrew J. Teichtahl, Graeme Jones… in BMC Musculoskeletal Disorders (2021)

Article

Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study.

Sultana Monira Hussain, Yuanyuan Wang, Alicia K. Heath… in BMC Musculoskeletal Disorders (2021)

Article

Association between clusters of back and joint pain with opioid use in middle-aged community-based women: a prospective cohort study

To determine the relationship between clusters of back pain and joint pain and prescription opioid dispensing.

Sultana Monira Hussain, Yuanyuan Wang, Geeske Peeters… in BMC Musculoskeletal Disorders (2021)

Article

Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial

Knee osteoarthritis is a major cause of pain and disability. Pain control is poor, with most patients remaining in moderate to severe pain. This may be because central causes of pain, a common contributor to k...

Anita E. Wluka, Donna M. Urquhart, Andrew J. Teichtahl… in BMC Musculoskeletal Disorders (2021)

Article

Person-centred care in osteoarthritis and inflammatory arthritis: a sco** review of people’s needs outside of healthcare

Arthritis, regardless of cause, has significant physical, social and psychological impacts on patients. We aimed to identify the non-healthcare needs perceived by patients with inflammatory arthritis (IA) and ...

Jessica L. Fairley, Maheeka Seneviwickrama, Sabrina Yeh… in BMC Musculoskeletal Disorders (2021)

Article

Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms

To describe demographic and clinical factors associated with the presence and incidence of depression and explore the temporal relationship between depression and joint symptoms in patients with symptomatic kn...

Shuang Zheng, Liudan Tu, Flavia Cicuttini, Zhaohua Zhu… in BMC Musculoskeletal Disorders (2021)

Article

Association between increased signal intensity at the proximal patellar tendon and patellofemoral geometry in community-based asymptomatic middle-aged adults: a cross-sectional study

Histological and epidemiological data suggest that increased signal intensity at the proximal patellar tendon on magnetic resonance imaging is a response to tendon loading. As patellofemoral geometry is a medi...

Robert D. Little, Samuel E. Smith, Flavia M. Cicuttini… in BMC Musculoskeletal Disorders (2020)

Article

Association between hip muscle cross-sectional area and hip pain and function in individuals with mild-to-moderate hip osteoarthritis: a cross-sectional study

To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.

Waruna L. Peiris, Flavia M. Cicuttini, Maria Constantinou… in BMC Musculoskeletal Disorders (2020)

Article

High baseline fat mass, but not lean tissue mass, is associated with high intensity low back pain and disability in community-based adults

Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d...

Sharmayne R. E. Brady, Donna M. Urquhart… in Arthritis Research & Therapy (2019)

Article

Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study

To examine whether metformin use was associated with knee cartilage volume loss over 4 years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.

Yuanyuan Wang, Sultana Monira Hussain, Anita E. Wluka… in Arthritis Research & Therapy (2019)

Article

A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2

Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and s...

Dawn Aitken, Laura L. Laslett, Guoqi Cai, Catherine Hill… in BMC Musculoskeletal Disorders (2018)

Article

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka… in Arthritis Research & Therapy (2017)

Article

Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study

Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...

Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2017)

Article

Lumbar disc degeneration is associated with modic change and high paraspinal fat content – a 3.0T magnetic resonance imaging study

Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: a multi-level study of Australian registry data

Associations between socioeconomic position (SEP) and the uptake of primary total shoulder arthroplasty (TSA) is not well understood in the Australian population, thus potentially limiting equitable allocation...

Sharon L. Brennan-Olsen, Richard S. Page, Stephen E. Lane… in BMC Musculoskeletal Disorders (2016)

Article

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Vertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Response to: ‘A dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine’—authors’ reply

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2016)