25 Result(s)

Article

METHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritis with Synovitis: study protocol for a randomised controlled trial

Hand osteoarthritis is a common and disabling problem without effective therapies. Accumulating evidence suggests the role of local inflammation in causing pain and structural progression in hand osteoarthriti...

Yuanyuan Wang, Andrew J. Teichtahl, Graeme Jones… in BMC Musculoskeletal Disorders (2021)

Article

Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial

Knee osteoarthritis is a major cause of pain and disability. Pain control is poor, with most patients remaining in moderate to severe pain. This may be because central causes of pain, a common contributor to k...

Anita E. Wluka, Donna M. Urquhart, Andrew J. Teichtahl… in BMC Musculoskeletal Disorders (2021)

Article

Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

There is evidence that knee pain not only is a consequence of structural deterioration in osteoarthritis (OA) but also contributes to structural progression. Clarifying this is important because targeting the ...

Yuanyuan Wang, Andrew J. Teichtahl, François Abram… in Arthritis Research & Therapy (2018)

Article

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka… in Arthritis Research & Therapy (2017)

Article

Lumbar disc degeneration is associated with modic change and high paraspinal fat content – a 3.0T magnetic resonance imaging study

Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Vertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined ...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in BMC Musculoskeletal Disorders (2016)

Article

Response to: ‘A dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine’—authors’ reply

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2016)

Article

A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss

The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing so are unclear. This longitudinal study determined whether the size of the IPFP (maximum cro...

Andrew J. Teichtahl, Ema Wulidasari, Sharmayne R. E. Brady… in Arthritis Research & Therapy (2015)

Article

A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine

Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between...

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2015)

Article

Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences

Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whethe...

Anita E. Wluka, Andrew J. Teichtahl, Rheza Maulana… in Arthritis Research & Therapy (2015)

Article

Wolff’s law in action: a mechanism for early knee osteoarthritis

There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such ke...

Andrew J. Teichtahl, Anita E. Wluka, Pushpika Wijethilake… in Arthritis Research & Therapy (2015)

Article

Weight change following knee and hip joint arthroplasty–a six-month prospective study of adults with osteoarthritis

Inconsistent findings of weight change following total knee (TKA) and hip (THA) arthroplasty may largely be attributable to heterogeneous cohorts and varied definitions of weight loss. This study examined weig...

Andrew J Teichtahl, Emma Quirk, Paula Harding… in BMC Musculoskeletal Disorders (2015)

Article

Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability

Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations ...

Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang… in Arthritis Research & Therapy (2015)

Article

Bone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults

The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abn...

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka… in Arthritis Research & Therapy (2015)

Article

Early cartilage abnormalities at the hip are associated with obesity and body composition measures – a 3.0T MRI community-based study

Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. This study examines whether the body mass index (BMI) and body composition are associated with h...

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka… in Arthritis Research & Therapy (2015)

Article

Occupational risk factors for hip osteoarthritis are associated with early hip structural abnormalities: a 3.0 T magnetic resonance imaging study of community-based adults

Occupational exposure to heavy lifting and stair climbing are associated with radiographic hip osteoarthritis (OA). This study examined whether these activities are associated with early structural hip joint c...

Andrew J Teichtahl, Sam Smith, Yuanyuan Wang, Anita E Wluka… in Arthritis Research & Therapy (2015)

Article

Structural changes of hip osteoarthritis using magnetic resonance imaging

Few data are available concerning structural changes at the hip observed by magnetic resonance imaging (MRI) in people with or without hip osteoarthritis (OA). The aim of this study was to compare cartilage vo...

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka… in Arthritis Research & Therapy (2014)

Article

Meniscal pathology - the evidence for treatment

Whilst arthroscopic surgery for the treatment of meniscal tears is the most commonly performed orthopaedic surgery, meniscal tears at the knee are frequently identified on magnetic resonance imaging in adults ...

Veronica Mezhov, Andrew J Teichtahl, Rupert Strasser… in Arthritis Research & Therapy (2014)

Article

The associations between body and knee height measurements and knee joint structure in an asymptomatic cohort

It has been suggested that knee height is a determinant of knee joint load. Nonetheless, no study has directly examined the relationship between anthropometric measures of height and knee joint structures, suc...

Andrew J Teichtahl, Anita E Wluka, Boyd J Strauss… in BMC Musculoskeletal Disorders (2012)