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Article
Open AccessAssociation between medial meniscal extrusion and knee structural progression in adults with symptomatic knee osteoarthritis — a prospective cohort study
To examine the association between medial meniscal extrusion and structural progression in adults with symptomatic knee osteoarthritis (OA).
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Article
Open AccessNonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial
Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of conducting a parallel group randomised trial to evaluate the effectiveness o...
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Article
Open AccessFunctional outcomes following knee replacement in community-dwelling older adults
Knee replacements are increasingly performed in older adults but uncertainty remains regarding their benefits in the context of age-related decline in physical function and other comorbidities. This study aim...
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Chapter
Osteoarthritis
Osteoarthritis (OA), the most common form of arthritis, has been recently estimated to affect 250 million people worldwide, with the numbers affected growing due to our increasingly aged and obese population. ...
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Article
Open AccessStudy protocol for a randomised controlled trial of diacerein versus placebo to treat knee osteoarthritis with effusion-synovitis (DICKENS)
There is an unmet need for treatments for knee osteoarthritis (OA). Effusion-synovitis is a common inflammatory phenotype of knee OA and predicts knee pain and structural degradation. Anti-inflammatory therapi...
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Article
Open AccessOsteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis
To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.
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Article
Open AccessEfficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials
There is some evidence that corticosteroids may have a beneficial effect in hand osteoarthritis. We examined the efficacy of corticosteroids on symptoms and structural outcomes in hand osteoarthritis.
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Article
Open AccessFootwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial
Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aims to determine the feasibility of conducting a fully-powered parallel group randomised trial to evaluate the ef...
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Article
Open AccessAssociation between arthritis and cardiovascular risk factors in community-based adults: an opportunity to target cardiovascular risk
Undertreated risk factors are major contributors to the burden of cardiovascular disease (CVD). Those with arthritis have an increased prevalence of CVD risk factors. CVD risk factors are often asymptomatic, w...
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Article
Open AccessTopical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial
Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies. Emerging evidence suggests the role of local inflammation in causing pain in hand osteoarthritis. Cortico...
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Article
Open AccessMETHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritis with Synovitis: study protocol for a randomised controlled trial
Hand osteoarthritis is a common and disabling problem without effective therapies. Accumulating evidence suggests the role of local inflammation in causing pain and structural progression in hand osteoarthriti...
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Article
Open AccessIs antibiotic treatment effective in the management of chronic low back pain with disc herniation? Study protocol for a randomised controlled trial
There has been immense interest and debate regarding the effectiveness of antibiotic treatment for chronic low back pain. Two randomised controlled trials have examined the efficacy of antibiotics for chronic ...
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Article
Open AccessAssociation between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study
To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study.
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Article
Open AccessAssociation between clusters of back and joint pain with opioid use in middle-aged community-based women: a prospective cohort study
To determine the relationship between clusters of back pain and joint pain and prescription opioid dispensing.
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Article
Open AccessEffect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial
Knee osteoarthritis is a major cause of pain and disability. Pain control is poor, with most patients remaining in moderate to severe pain. This may be because central causes of pain, a common contributor to k...
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Article
Open AccessPerson-centred care in osteoarthritis and inflammatory arthritis: a sco** review of people’s needs outside of healthcare
Arthritis, regardless of cause, has significant physical, social and psychological impacts on patients. We aimed to identify the non-healthcare needs perceived by patients with inflammatory arthritis (IA) and ...
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Article
Open AccessDepression in patients with knee osteoarthritis: risk factors and associations with joint symptoms
To describe demographic and clinical factors associated with the presence and incidence of depression and explore the temporal relationship between depression and joint symptoms in patients with symptomatic kn...
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Article
Open AccessAssociation between increased signal intensity at the proximal patellar tendon and patellofemoral geometry in community-based asymptomatic middle-aged adults: a cross-sectional study
Histological and epidemiological data suggest that increased signal intensity at the proximal patellar tendon on magnetic resonance imaging is a response to tendon loading. As patellofemoral geometry is a medi...
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Article
Open AccessAssociation between hip muscle cross-sectional area and hip pain and function in individuals with mild-to-moderate hip osteoarthritis: a cross-sectional study
To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.
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Article
Open AccessHigh baseline fat mass, but not lean tissue mass, is associated with high intensity low back pain and disability in community-based adults
Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d...
