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Article
Open AccessAssociation between medial meniscal extrusion and knee structural progression in adults with symptomatic knee osteoarthritis — a prospective cohort study
To examine the association between medial meniscal extrusion and structural progression in adults with symptomatic knee osteoarthritis (OA).
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Article
Open AccessNonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial
Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of conducting a parallel group randomised trial to evaluate the effectiveness o...
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Osteoarthritis
Osteoarthritis (OA), the most common form of arthritis, has been recently estimated to affect 250 million people worldwide, with the numbers affected growing due to our increasingly aged and obese population. ...
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Article
Open AccessOsteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis
To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.
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Article
Open AccessEfficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials
There is some evidence that corticosteroids may have a beneficial effect in hand osteoarthritis. We examined the efficacy of corticosteroids on symptoms and structural outcomes in hand osteoarthritis.
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Article
Open AccessFootwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial
Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aims to determine the feasibility of conducting a fully-powered parallel group randomised trial to evaluate the ef...
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Article
Open AccessTopical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial
Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies. Emerging evidence suggests the role of local inflammation in causing pain in hand osteoarthritis. Cortico...
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Open AccessMETHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritis with Synovitis: study protocol for a randomised controlled trial
Hand osteoarthritis is a common and disabling problem without effective therapies. Accumulating evidence suggests the role of local inflammation in causing pain and structural progression in hand osteoarthriti...
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Article
Open AccessAssociation between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study
To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study.
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Article
Open AccessAssociation between clusters of back and joint pain with opioid use in middle-aged community-based women: a prospective cohort study
To determine the relationship between clusters of back pain and joint pain and prescription opioid dispensing.
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Article
Open AccessEffect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial
Knee osteoarthritis is a major cause of pain and disability. Pain control is poor, with most patients remaining in moderate to severe pain. This may be because central causes of pain, a common contributor to k...
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Open AccessPerson-centred care in osteoarthritis and inflammatory arthritis: a sco** review of people’s needs outside of healthcare
Arthritis, regardless of cause, has significant physical, social and psychological impacts on patients. We aimed to identify the non-healthcare needs perceived by patients with inflammatory arthritis (IA) and ...
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Article
Open AccessDepression in patients with knee osteoarthritis: risk factors and associations with joint symptoms
To describe demographic and clinical factors associated with the presence and incidence of depression and explore the temporal relationship between depression and joint symptoms in patients with symptomatic kn...
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Article
Open AccessAssociation between increased signal intensity at the proximal patellar tendon and patellofemoral geometry in community-based asymptomatic middle-aged adults: a cross-sectional study
Histological and epidemiological data suggest that increased signal intensity at the proximal patellar tendon on magnetic resonance imaging is a response to tendon loading. As patellofemoral geometry is a medi...
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Open AccessAssociation between hip muscle cross-sectional area and hip pain and function in individuals with mild-to-moderate hip osteoarthritis: a cross-sectional study
To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.
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Article
Open AccessHigh baseline fat mass, but not lean tissue mass, is associated with high intensity low back pain and disability in community-based adults
Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d...
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Open AccessAssociation between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study
To examine whether metformin use was associated with knee cartilage volume loss over 4 years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.
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Article
Open AccessA protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2
Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and s...
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Open AccessIncrease in body weight over a two-year period is associated with an increase in midfoot pressure and foot pain
There is a well-recognised relationship between body weight, plantar pressures and foot pain, but the temporal association between these factors is unknown. The aim of this study was to investigate the relatio...
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Open AccessAssociations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study
Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...